Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging

Z. Z. Spector, K. Emami, M. C. Fischer, J. Zhu, M. Ishii, V. Vahdat, J. Yu, S. Kadlecek, B. Driehuys, D. A. Lipson, W. Gefter, J. Shrager, Rahim R. Rizi

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


In this experiment, Sprague-Dawley rats with elastase-induced emphysema were imaged using hyperpolarized 3He MRI. Regional fractional ventilation r, the fraction of gas replaced with a single tidal breath, was calculated from a series of images in a wash-in study of hyperpolarized gas. We compared the regional fractional ventilation in these emphysematous rats to the regional fractional ventilations we calculated from a previous baseline study in healthy Sprague-Dawley rats. We found that there were differences in the maps of fractional ventilation and its associated frequency distribution between the healthy and emphysematous rat lungs. Fractional ventilation tended to be much lower in emphysematous rats than in normal rats. With this information, we can use data on fractional ventilation to regionally distinguish between healthy and emphysematous portions of the lung. The successful implementation of such a technique on a rat model could lead to work toward the future implementation of this technique in human patients.

Original languageEnglish (US)
Pages (from-to)1341-1346
Number of pages6
JournalMagnetic resonance in medicine
Issue number6
StatePublished - Jun 2005


  • Functional lung imaging
  • Hyperpolarized He
  • Hyperpolarized gas MRI
  • Lung ventilation
  • MRI
  • Pulmonary emphysema

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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