Quantitative and statistical analyses of PET imaging studies of amyloid deposition in humans

J. C. Price; S. K. Ziolko; L. A. Weissfeld; W. E. Klunk; X. Lu; J. A. Hoge; C. C. Meltzer; S. W. Davis; B. J. Lopresti; D. P. Holt; S. T. DeKosky; C. A. Mathis

Quantitative and statistical analyses of PET imaging studies of amyloid deposition in humans

J. C. Price, S. K. Ziolko, L. A. Weissfeld, W. E. Klunk, X. Lu, J. A. Hoge, C. C. Meltzer, S. W. Davis, B. J. Lopresti, D. P. Holt, S. T. DeKosky, C. A. Mathis

Research output: Contribution to journal › Conference article › peer-review

6 Scopus citations

Abstract

In vivo amyloid imaging could aid in earlier detection of Alzheimer's disease (AD) and anti-amyloid therapy development. We compared quantitative region-of-interest (ROI) and voxel-based statistical analyses of positron emission tomography (PET) studies of the ¹¹C-labeled amyloid-imaging agent, PIB. High specific activity PIB PET studies were performed in 5 AD and 5 control subjects (ECAT HR+, 10-15 mCi, arterial input, 90 min). Magnetic resonance (MR) imaging was performed (ROI delineation). Quantitative analyses yielded regional PIB retention values (i.e., DVratio (DVR): radiotracer distribution volume (DV) normalized to the cerebellar reference DV). Statistical Parametric Mapping (SPM) and Partial Least Squares (PLS) analyses were applied to PIB DVR images (arterial based) that were spatially normalized to an elderly MR template (55-90 years, n=268). The regional tissue response functions (fast and slow kinetic components) were consistent with the DVR values. The ROI, SPM (p < .025, 50 voxel extent, false discovery correction), and PLS (saliences) analyses yielded marked PIB retention in areas of AD brain that were consistent with known areas of amyloid deposition in AD, as compared to reference retention in areas unaffected by amyloid in AD (white matter, cerebellum, control brain). Voxel-based analyses of PIB PET data will likely prove valid and robust for mapping amyloid deposition on a cross-sectional and longitudinal basis in AD.

Original language	English (US)
Article number	M5-342
Pages (from-to)	3161-3164
Number of pages	4
Journal	IEEE Nuclear Science Symposium Conference Record
Volume	5
State	Published - 2004
Externally published	Yes
Event	2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors - Rome, Italy Duration: Oct 16 2004 → Oct 22 2004

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

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@article{136cbd4d081641d2b795313154aca918,

title = "Quantitative and statistical analyses of PET imaging studies of amyloid deposition in humans",

abstract = "In vivo amyloid imaging could aid in earlier detection of Alzheimer's disease (AD) and anti-amyloid therapy development. We compared quantitative region-of-interest (ROI) and voxel-based statistical analyses of positron emission tomography (PET) studies of the 11C-labeled amyloid-imaging agent, PIB. High specific activity PIB PET studies were performed in 5 AD and 5 control subjects (ECAT HR+, 10-15 mCi, arterial input, 90 min). Magnetic resonance (MR) imaging was performed (ROI delineation). Quantitative analyses yielded regional PIB retention values (i.e., DVratio (DVR): radiotracer distribution volume (DV) normalized to the cerebellar reference DV). Statistical Parametric Mapping (SPM) and Partial Least Squares (PLS) analyses were applied to PIB DVR images (arterial based) that were spatially normalized to an elderly MR template (55-90 years, n=268). The regional tissue response functions (fast and slow kinetic components) were consistent with the DVR values. The ROI, SPM (p < .025, 50 voxel extent, false discovery correction), and PLS (saliences) analyses yielded marked PIB retention in areas of AD brain that were consistent with known areas of amyloid deposition in AD, as compared to reference retention in areas unaffected by amyloid in AD (white matter, cerebellum, control brain). Voxel-based analyses of PIB PET data will likely prove valid and robust for mapping amyloid deposition on a cross-sectional and longitudinal basis in AD.",

author = "Price, {J. C.} and Ziolko, {S. K.} and Weissfeld, {L. A.} and Klunk, {W. E.} and X. Lu and Hoge, {J. A.} and Meltzer, {C. C.} and Davis, {S. W.} and Lopresti, {B. J.} and Holt, {D. P.} and DeKosky, {S. T.} and Mathis, {C. A.}",

year = "2004",

language = "English (US)",

volume = "5",

pages = "3161--3164",

journal = "IEEE Nuclear Science Symposium Conference Record",

issn = "1095-7863",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors ; Conference date: 16-10-2004 Through 22-10-2004",

}

TY - JOUR

T1 - Quantitative and statistical analyses of PET imaging studies of amyloid deposition in humans

AU - Price, J. C.

AU - Ziolko, S. K.

AU - Weissfeld, L. A.

AU - Klunk, W. E.

AU - Lu, X.

AU - Hoge, J. A.

AU - Meltzer, C. C.

AU - Davis, S. W.

AU - Lopresti, B. J.

AU - Holt, D. P.

AU - DeKosky, S. T.

AU - Mathis, C. A.

PY - 2004

Y1 - 2004

N2 - In vivo amyloid imaging could aid in earlier detection of Alzheimer's disease (AD) and anti-amyloid therapy development. We compared quantitative region-of-interest (ROI) and voxel-based statistical analyses of positron emission tomography (PET) studies of the 11C-labeled amyloid-imaging agent, PIB. High specific activity PIB PET studies were performed in 5 AD and 5 control subjects (ECAT HR+, 10-15 mCi, arterial input, 90 min). Magnetic resonance (MR) imaging was performed (ROI delineation). Quantitative analyses yielded regional PIB retention values (i.e., DVratio (DVR): radiotracer distribution volume (DV) normalized to the cerebellar reference DV). Statistical Parametric Mapping (SPM) and Partial Least Squares (PLS) analyses were applied to PIB DVR images (arterial based) that were spatially normalized to an elderly MR template (55-90 years, n=268). The regional tissue response functions (fast and slow kinetic components) were consistent with the DVR values. The ROI, SPM (p < .025, 50 voxel extent, false discovery correction), and PLS (saliences) analyses yielded marked PIB retention in areas of AD brain that were consistent with known areas of amyloid deposition in AD, as compared to reference retention in areas unaffected by amyloid in AD (white matter, cerebellum, control brain). Voxel-based analyses of PIB PET data will likely prove valid and robust for mapping amyloid deposition on a cross-sectional and longitudinal basis in AD.

AB - In vivo amyloid imaging could aid in earlier detection of Alzheimer's disease (AD) and anti-amyloid therapy development. We compared quantitative region-of-interest (ROI) and voxel-based statistical analyses of positron emission tomography (PET) studies of the 11C-labeled amyloid-imaging agent, PIB. High specific activity PIB PET studies were performed in 5 AD and 5 control subjects (ECAT HR+, 10-15 mCi, arterial input, 90 min). Magnetic resonance (MR) imaging was performed (ROI delineation). Quantitative analyses yielded regional PIB retention values (i.e., DVratio (DVR): radiotracer distribution volume (DV) normalized to the cerebellar reference DV). Statistical Parametric Mapping (SPM) and Partial Least Squares (PLS) analyses were applied to PIB DVR images (arterial based) that were spatially normalized to an elderly MR template (55-90 years, n=268). The regional tissue response functions (fast and slow kinetic components) were consistent with the DVR values. The ROI, SPM (p < .025, 50 voxel extent, false discovery correction), and PLS (saliences) analyses yielded marked PIB retention in areas of AD brain that were consistent with known areas of amyloid deposition in AD, as compared to reference retention in areas unaffected by amyloid in AD (white matter, cerebellum, control brain). Voxel-based analyses of PIB PET data will likely prove valid and robust for mapping amyloid deposition on a cross-sectional and longitudinal basis in AD.

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UR - http://www.scopus.com/inward/citedby.url?scp=23844466409&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:23844466409

SN - 1095-7863

VL - 5

SP - 3161

EP - 3164

JO - IEEE Nuclear Science Symposium Conference Record

JF - IEEE Nuclear Science Symposium Conference Record

M1 - M5-342

T2 - 2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors

Y2 - 16 October 2004 through 22 October 2004

ER -

Quantitative and statistical analyses of PET imaging studies of amyloid deposition in humans

Abstract

ASJC Scopus subject areas

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