Quantifying Phase- Amplitude Modulation in Neural Data

Victoria Subritzky-Katz; Aaron L. Sampson; Erik Emeric; Witold Lipski; Sophia Moreira-Gonzalez; Jorge Gonzalez-Martinez; Sridevi Sarma; Veit Stuphorn; Ernst Niebur

doi:10.1109/CISS56502.2023.10089691

Quantifying Phase- Amplitude Modulation in Neural Data

Victoria Subritzky-Katz, Aaron L. Sampson, Erik Emeric, Witold Lipski, Sophia Moreira-Gonzalez, Jorge Gonzalez-Martinez, Sridevi Sarma, Veit Stuphorn, Ernst Niebur

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Phase-amplitude modulation (the modulation of the amplitude of higher frequency oscillations by the phase of lower frequency oscillations) is a specific type of cross-frequency coupling that has been observed in neural recordings from multiple species in a range of behavioral contexts. Given its potential importance, care must be taken with how it is measured and quantified. Previous studies have quantified phase-amplitude modulation by measuring the distance of the amplitude distribution from a uniform distribution. While this method is of general applicability, it is not targeted to the specific modulation pattern frequently observed with low-frequency oscillations. Here we develop a new method that has increased specificity to detect modulation in the sinusoidal shape commonly observed in neural data.

Original language	English (US)
Title of host publication	2023 57th Annual Conference on Information Sciences and Systems, CISS 2023
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781665451819
DOIs	https://doi.org/10.1109/CISS56502.2023.10089691
State	Published - 2023
Event	57th Annual Conference on Information Sciences and Systems, CISS 2023 - Baltimore, United States Duration: Mar 22 2023 → Mar 24 2023

Publication series

Name	2023 57th Annual Conference on Information Sciences and Systems, CISS 2023

Conference

Conference	57th Annual Conference on Information Sciences and Systems, CISS 2023
Country/Territory	United States
City	Baltimore
Period	3/22/23 → 3/24/23

Keywords

ECoG
EEG
cross-frequency coupling
phase-amplitude modulation
sEEG

ASJC Scopus subject areas

Computer Science Applications
Hardware and Architecture
Information Systems
Artificial Intelligence
Information Systems and Management
Safety, Risk, Reliability and Quality

Access to Document

10.1109/CISS56502.2023.10089691

Cite this

Subritzky-Katz, V., Sampson, A. L., Emeric, E., Lipski, W., Moreira-Gonzalez, S., Gonzalez-Martinez, J., Sarma, S., Stuphorn, V., & Niebur, E. (2023). Quantifying Phase- Amplitude Modulation in Neural Data. In 2023 57th Annual Conference on Information Sciences and Systems, CISS 2023 (2023 57th Annual Conference on Information Sciences and Systems, CISS 2023). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CISS56502.2023.10089691

Quantifying Phase- Amplitude Modulation in Neural Data. / Subritzky-Katz, Victoria; Sampson, Aaron L.; Emeric, Erik et al.
2023 57th Annual Conference on Information Sciences and Systems, CISS 2023. Institute of Electrical and Electronics Engineers Inc., 2023. (2023 57th Annual Conference on Information Sciences and Systems, CISS 2023).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Subritzky-Katz, V, Sampson, AL, Emeric, E, Lipski, W, Moreira-Gonzalez, S, Gonzalez-Martinez, J, Sarma, S , Stuphorn, V & Niebur, E 2023, Quantifying Phase- Amplitude Modulation in Neural Data. in 2023 57th Annual Conference on Information Sciences and Systems, CISS 2023. 2023 57th Annual Conference on Information Sciences and Systems, CISS 2023, Institute of Electrical and Electronics Engineers Inc., 57th Annual Conference on Information Sciences and Systems, CISS 2023, Baltimore, United States, 3/22/23. https://doi.org/10.1109/CISS56502.2023.10089691

Subritzky-Katz V, Sampson AL, Emeric E, Lipski W, Moreira-Gonzalez S, Gonzalez-Martinez J et al. Quantifying Phase- Amplitude Modulation in Neural Data. In 2023 57th Annual Conference on Information Sciences and Systems, CISS 2023. Institute of Electrical and Electronics Engineers Inc. 2023. (2023 57th Annual Conference on Information Sciences and Systems, CISS 2023). doi: 10.1109/CISS56502.2023.10089691

@inproceedings{6aaba07abca44660b46ca6ba6bef7538,

title = "Quantifying Phase- Amplitude Modulation in Neural Data",

abstract = "Phase-amplitude modulation (the modulation of the amplitude of higher frequency oscillations by the phase of lower frequency oscillations) is a specific type of cross-frequency coupling that has been observed in neural recordings from multiple species in a range of behavioral contexts. Given its potential importance, care must be taken with how it is measured and quantified. Previous studies have quantified phase-amplitude modulation by measuring the distance of the amplitude distribution from a uniform distribution. While this method is of general applicability, it is not targeted to the specific modulation pattern frequently observed with low-frequency oscillations. Here we develop a new method that has increased specificity to detect modulation in the sinusoidal shape commonly observed in neural data.",

keywords = "ECoG, EEG, cross-frequency coupling, phase-amplitude modulation, sEEG",

author = "Victoria Subritzky-Katz and Sampson, {Aaron L.} and Erik Emeric and Witold Lipski and Sophia Moreira-Gonzalez and Jorge Gonzalez-Martinez and Sridevi Sarma and Veit Stuphorn and Ernst Niebur",

note = "Publisher Copyright: {\textcopyright} 2023 IEEE.; 57th Annual Conference on Information Sciences and Systems, CISS 2023 ; Conference date: 22-03-2023 Through 24-03-2023",

year = "2023",

doi = "10.1109/CISS56502.2023.10089691",

language = "English (US)",

series = "2023 57th Annual Conference on Information Sciences and Systems, CISS 2023",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

booktitle = "2023 57th Annual Conference on Information Sciences and Systems, CISS 2023",

}

TY - GEN

T1 - Quantifying Phase- Amplitude Modulation in Neural Data

AU - Subritzky-Katz, Victoria

AU - Sampson, Aaron L.

AU - Emeric, Erik

AU - Lipski, Witold

AU - Moreira-Gonzalez, Sophia

AU - Gonzalez-Martinez, Jorge

AU - Sarma, Sridevi

AU - Stuphorn, Veit

AU - Niebur, Ernst

PY - 2023

Y1 - 2023

N2 - Phase-amplitude modulation (the modulation of the amplitude of higher frequency oscillations by the phase of lower frequency oscillations) is a specific type of cross-frequency coupling that has been observed in neural recordings from multiple species in a range of behavioral contexts. Given its potential importance, care must be taken with how it is measured and quantified. Previous studies have quantified phase-amplitude modulation by measuring the distance of the amplitude distribution from a uniform distribution. While this method is of general applicability, it is not targeted to the specific modulation pattern frequently observed with low-frequency oscillations. Here we develop a new method that has increased specificity to detect modulation in the sinusoidal shape commonly observed in neural data.

AB - Phase-amplitude modulation (the modulation of the amplitude of higher frequency oscillations by the phase of lower frequency oscillations) is a specific type of cross-frequency coupling that has been observed in neural recordings from multiple species in a range of behavioral contexts. Given its potential importance, care must be taken with how it is measured and quantified. Previous studies have quantified phase-amplitude modulation by measuring the distance of the amplitude distribution from a uniform distribution. While this method is of general applicability, it is not targeted to the specific modulation pattern frequently observed with low-frequency oscillations. Here we develop a new method that has increased specificity to detect modulation in the sinusoidal shape commonly observed in neural data.

KW - ECoG

KW - EEG

KW - cross-frequency coupling

KW - phase-amplitude modulation

KW - sEEG

UR - http://www.scopus.com/inward/record.url?scp=85154063148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85154063148&partnerID=8YFLogxK

U2 - 10.1109/CISS56502.2023.10089691

DO - 10.1109/CISS56502.2023.10089691

M3 - Conference contribution

C2 - 38250522

AN - SCOPUS:85154063148

T3 - 2023 57th Annual Conference on Information Sciences and Systems, CISS 2023

BT - 2023 57th Annual Conference on Information Sciences and Systems, CISS 2023

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 57th Annual Conference on Information Sciences and Systems, CISS 2023

Y2 - 22 March 2023 through 24 March 2023

ER -

Quantifying Phase- Amplitude Modulation in Neural Data

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this