Quantifying focal disruptions in axonal microtubules

R. M. Dastgheyb; K. A. Barbee; G. Gallo

doi:10.1109/NEBEC.2015.7117155

Quantifying focal disruptions in axonal microtubules

R. M. Dastgheyb, K. A. Barbee, G. Gallo

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Focal disruptions in axonal microtubules are a common consequence of Traumatic Brain Injuries (TBIs), and the ability to quantify these disruptions is essential to evaluating in vitro injury models and therapies. Here, we develop and implement an algorithm to demonstrate the ability to quantify focal disruptions in the microtubules of cultured neurons. The algorithm is implemented using a combination of ImageJ for pre-processing and Matlab for axon analysis and tubulin breakdown identification.

Original language	English (US)
Title of host publication	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479983605
DOIs	https://doi.org/10.1109/NEBEC.2015.7117155
State	Published - Jun 2 2015
Externally published	Yes
Event	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States Duration: Apr 17 2015 → Apr 19 2015

Publication series

Name	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

Other

Other	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Country/Territory	United States
City	Troy
Period	4/17/15 → 4/19/15

ASJC Scopus subject areas

Biotechnology
Cancer Research
Cell Biology
Molecular Medicine
Biomedical Engineering
Control and Systems Engineering

Access to Document

10.1109/NEBEC.2015.7117155

Cite this

Quantifying focal disruptions in axonal microtubules. / Dastgheyb, R. M.; Barbee, K. A.; Gallo, G.
2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7117155 (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Dastgheyb, RM, Barbee, KA & Gallo, G 2015, Quantifying focal disruptions in axonal microtubules. in 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015., 7117155, 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Institute of Electrical and Electronics Engineers Inc., 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Troy, United States, 4/17/15. https://doi.org/10.1109/NEBEC.2015.7117155

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Quantifying focal disruptions in axonal microtubules

Abstract

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Other

ASJC Scopus subject areas

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