@inbook{24b5a30e0925403ab5cb3cf77b7fd4a0,
title = "Quantifying argonaute proteins in and out of GW/P-bodies: Implications in microRNA activities",
abstract = "MicroRNAs (miRNAs) are a class of ∼22nt non-coding RNAs that regulate the translational potential and stability of mRNAs. Though constituting only 1-4% of human genes, miRNAs are predicted to regulate more than 60% of all mRNAs. The action of miRNAs is mediated through their associations with Argonaute proteins and mRNA targets. Previous studies indicated that though the majority of Argonaute proteins is diffusely distributed in the cytoplasm, a small fraction is consistently observed to be concentrated in a cytoplasmic compartment called GW/P-bodies. In this chapter, we will provide a quantitative and dynamic view of the subcellular localization of miRNA function, followed by a discussion on the possible roles of PBs in miRNA silencing.",
author = "Leung, {Anthony K.L.} and Sharp, {Phillip A.}",
note = "Funding Information: We thank M. Lindstrom for figure illustrations. This work was supported by R01-CA133404 from NIH, P01-CA42063 from NCI to PAS and partially by Cancer Center Support (core) grant P30-CA14051 from NCI. AKLL was a special fellow of the Leukemia and Lymphoma Society and is supported by a DOD Breast Cancer Research Program Idea Award #BC101881.",
year = "2013",
doi = "10.1007/978-1-4614-5107-5_10",
language = "English (US)",
isbn = "9781461451068",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer Science and Business Media, LLC",
pages = "165--182",
booktitle = "Ten Years of Progress in GW/P Body Research",
}