TY - JOUR
T1 - Quality of life in chronic pancreatitis
T2 - A prospective trial comparing classical whipple procedure and duodenum-preserving pancreatic head resection
AU - Witzigmann, Helmut
AU - Max, Doreen
AU - Uhlmann, Dirk
AU - Geißler, Felix
AU - Ludwig, Stefan
AU - Schwarz, Reinhold
AU - Krauß, Oliver
AU - Lohmann, Tobias
AU - Keim, Volker
AU - Hauss, Johann
AU - Zenilman, M.
AU - Sarr, M.
AU - Traverso, L.
AU - Bell, R.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Few data are available with respect to quality of life after pancreatic head resection in patients with chronic pancreatitis. The aim of this study was to compare the classical Whipple pancreatoduodenectomy (PD) with the Beger duodenum-preserving pancreatic head resection (DPPHR), in terms of quality of life, using standardized, valid, and reliable questionnaires. Sixty-five consecutive patients were included in this study. The PD procedure was chosen when pancreatic cancer could not be ruled out (n = 30); otherwise DPPHR was performed (n = 35). Quality of life was measured prospectively three times with the European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire (QLQ-C30) and the Gastrointestinal Quality-of-Life Index (GIQLI). Both procedures led to a significant improvement in quality of life, especially with regard to pain status. However, at the second followup examination (18 to 24 months postoperatively), all functional scales and the most important symptom scales of the EORTC QLQ-C30 revealed a better quality of life in the DPPHR group compared to the PD group. After classical PD, more patients seem to develop diabetes mellitus. The EORTC QLQ-C30 was found to be a better tool for quality-of-life assessment than the GIQLI in patients with chronic pancreatitis.
AB - Few data are available with respect to quality of life after pancreatic head resection in patients with chronic pancreatitis. The aim of this study was to compare the classical Whipple pancreatoduodenectomy (PD) with the Beger duodenum-preserving pancreatic head resection (DPPHR), in terms of quality of life, using standardized, valid, and reliable questionnaires. Sixty-five consecutive patients were included in this study. The PD procedure was chosen when pancreatic cancer could not be ruled out (n = 30); otherwise DPPHR was performed (n = 35). Quality of life was measured prospectively three times with the European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire (QLQ-C30) and the Gastrointestinal Quality-of-Life Index (GIQLI). Both procedures led to a significant improvement in quality of life, especially with regard to pain status. However, at the second followup examination (18 to 24 months postoperatively), all functional scales and the most important symptom scales of the EORTC QLQ-C30 revealed a better quality of life in the DPPHR group compared to the PD group. After classical PD, more patients seem to develop diabetes mellitus. The EORTC QLQ-C30 was found to be a better tool for quality-of-life assessment than the GIQLI in patients with chronic pancreatitis.
KW - Chronic pancreatitis
KW - Duodenum-preserving pancreatic head resection
KW - Pancreatoduodenectomy
KW - Quality of life
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U2 - 10.1016/S1091-255X(01)00023-3
DO - 10.1016/S1091-255X(01)00023-3
M3 - Article
C2 - 11992802
AN - SCOPUS:15944399980
SN - 1091-255X
VL - 6
SP - 173
EP - 180
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 2
ER -