TY - JOUR
T1 - Quality of life after acute respiratory distress syndrome
T2 - A meta-analysis
AU - Dowdy, David W.
AU - Eid, Mark P.
AU - Dennison, Cheryl R.
AU - Mendez-Tellez, Pedro A.
AU - Herridge, Margaret S.
AU - Guallar, Eliseo
AU - Pronovost, Peter J.
AU - Needham, Dale M.
N1 - Funding Information:
Received: 13 January 2006 Accepted: 2 May 2006 Published online: 17 June 2006 © Springer-Verlag 2006 This research is supported by National Institutes of Health (ALI SCCOR Grant # P050 HL 73994). D.W.D. is supported by a Medical Scientist Training Program Grant from the National Institutes of Health (Award # 5 T32 GMO7309). D.M.N. is supported by a Clinician-Scientist Award from the Canadian Institutes of Health Research and a Detweiler Fellowship from the Royal College of Physicians and Surgeons of Canada.
PY - 2006/8
Y1 - 2006/8
N2 - Objective: To summarize long-term quality of life (QOL) and the degree of variation in QOL estimates across studies of acute respiratory distress (ARDS) survivors. Design: A systematic review of studies evaluating QOL in ARDS survivors was conducted. Medline, EMBASE, CINAHL, pre-CINAHL, and the Cochrane Library were searched, and reference lists from relevant articles were evaluated. Two authors independently selected studies reporting QOL in adult survivors of ARDS or acute lung injury at least 30 days after intensive care unit discharge and extracted data on study design, patient characteristics, methods, and results. Measurements and results: Thirteen independent observational studies (557 patients) met inclusion criteria. Eight of these studies used eight different QOL instruments, allowing only qualitative synthesis of results. The five remaining studies (330 patients) measured QOL using the Medical Outcomes Study 36-Item Short Form survey (SF-36). Mean QOL scores were similar across these studies, falling within a range of 20 points for all domains. Pooled domain-specific QOL scores in ARDS survivors 6 months or later after discharge ranged from 45 (role physical) to 66 (social functioning), or 15-26 points lower than population norms, in all domains except mental health (11 points) and role physical (39 points). Corresponding confidence intervals were no wider than ± 9 points. Six studies all found stable or improved QOL over time, but only one found significant improvement beyond 6 months after discharge. Conclusions: ARDS survivors in different clinical settings experience similar decrements in QOL. The precise magnitude of these decrements helps clarify the long-term prognosis for ARDS survivors.
AB - Objective: To summarize long-term quality of life (QOL) and the degree of variation in QOL estimates across studies of acute respiratory distress (ARDS) survivors. Design: A systematic review of studies evaluating QOL in ARDS survivors was conducted. Medline, EMBASE, CINAHL, pre-CINAHL, and the Cochrane Library were searched, and reference lists from relevant articles were evaluated. Two authors independently selected studies reporting QOL in adult survivors of ARDS or acute lung injury at least 30 days after intensive care unit discharge and extracted data on study design, patient characteristics, methods, and results. Measurements and results: Thirteen independent observational studies (557 patients) met inclusion criteria. Eight of these studies used eight different QOL instruments, allowing only qualitative synthesis of results. The five remaining studies (330 patients) measured QOL using the Medical Outcomes Study 36-Item Short Form survey (SF-36). Mean QOL scores were similar across these studies, falling within a range of 20 points for all domains. Pooled domain-specific QOL scores in ARDS survivors 6 months or later after discharge ranged from 45 (role physical) to 66 (social functioning), or 15-26 points lower than population norms, in all domains except mental health (11 points) and role physical (39 points). Corresponding confidence intervals were no wider than ± 9 points. Six studies all found stable or improved QOL over time, but only one found significant improvement beyond 6 months after discharge. Conclusions: ARDS survivors in different clinical settings experience similar decrements in QOL. The precise magnitude of these decrements helps clarify the long-term prognosis for ARDS survivors.
KW - Critical care
KW - Critical illness
KW - Intensive care units
KW - Outcome assessment (health care)
KW - Quality of life
KW - Respiratory distress syndrome, adult
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U2 - 10.1007/s00134-006-0217-3
DO - 10.1007/s00134-006-0217-3
M3 - Review article
C2 - 16783553
AN - SCOPUS:33747180789
SN - 0342-4642
VL - 32
SP - 1115
EP - 1124
JO - Intensive Care Medicine
JF - Intensive Care Medicine
IS - 8
ER -