TY - JOUR
T1 - Quality of evidence in drug compendia supporting off-label use of typical and atypical antipsychotic medications
AU - Paczynski, Richard P.
AU - Alexander, G. Caleb
AU - Chinchilli, Vernon M.
AU - Kruszewski, Stefan P.
PY - 2012
Y1 - 2012
N2 - Public and private payers use drug compendia to make coverage determinations, yet the quality of evidence they contain has received little scrutiny. We examined compendia citations regarding antipsychotic drugs, an important drug class given their substantial costs and widespread use. Nearly three-fold as many off-label indications were recommended for atypical as for typical agents, a difference that did not appear to be due to differences in quality of evidence for typical and atypical off-label indications. Given the important role that compendia play in evidence synthesis, coverage decisions, and ultimately, prescription utilization, these data suggest greater efforts are needed to improve the quality of evidence and transparency of evidence evaluations compendia contain.
AB - Public and private payers use drug compendia to make coverage determinations, yet the quality of evidence they contain has received little scrutiny. We examined compendia citations regarding antipsychotic drugs, an important drug class given their substantial costs and widespread use. Nearly three-fold as many off-label indications were recommended for atypical as for typical agents, a difference that did not appear to be due to differences in quality of evidence for typical and atypical off-label indications. Given the important role that compendia play in evidence synthesis, coverage decisions, and ultimately, prescription utilization, these data suggest greater efforts are needed to improve the quality of evidence and transparency of evidence evaluations compendia contain.
KW - Drug compendia
KW - antipsychotics
KW - conflict of interest
KW - recommendations for use
KW - resource utilization
UR - http://www.scopus.com/inward/record.url?scp=84866642808&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866642808&partnerID=8YFLogxK
U2 - 10.3233/JRS-2012-0567
DO - 10.3233/JRS-2012-0567
M3 - Article
C2 - 22936056
AN - SCOPUS:84866642808
SN - 0924-6479
VL - 24
SP - 137
EP - 146
JO - International Journal of Risk and Safety in Medicine
JF - International Journal of Risk and Safety in Medicine
IS - 3
ER -