Qualitative perspective on the learning health system: How the community health applied research network paved the way for research in safety-net settings

Background: Safety-net populations are underrepresented in health research networks. To address this deficit, the Community Health Applied Research Network (CHARN) was created to promote integration of research in health centers (HCs). CHARN embodies a learning health system (LHS) model to advance the evidence base for improved care in safety-net settings. Objectives: We sought to identify lessons learned from the development of research infrastructure to promote the inclusion of safety-net populations in research. Methods: We conducted nine qualitative interviews with a purposive sample of CHARN members, as well as content analysis of work plans and project reports, and identified barriers and facilitators to building research capacity in HCs. Results: Lessons learned include the importance of linking research to the HC mission, encouraging mentoring, and investing in data infrastructure at HCs to tailor health services to communities. Conclusions: Findings can inform safety-net providers on the process of building research infrastructure and capacity.