QTc dispersion and P-wave dispersion during migraine attacks

M. Duru, I. Melek, E. Seyfeli, T. Duman, G. Kuvandik, H. Kaya, F. Yalçin

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The aim of this study was to investigate increase of QTc dispersion and P-wave dispersion during migraine attacks. Fifty-five patients (16-65 years of age, 49 women, six men) with migraine were included in our study. Heart rate, QTc interval, maximum and minimum QTc interval, QTc dispersion, maximum and minimum P-wave duration and P-wave dispersion were measured from 12-lead ECG recording during migraine attacks and pain-free periods. ECGs were transferred to a personal computer via a scanner and then used for magnification of ×400 by Adobe Photoshop software. Maximum QTc interval (454 ± 24 ms vs. 429 ± 23 ms, P <0.001), QTc interval (443 ± 26 ms vs. 408 ± 22 ms, P <0.001) and QTc dispersion (63 ± 18 ms vs. 43 ± 14 ms, P <0.001) were found significantly higher during migraine attacks compared with pain-free periods. Maximum P-wave duration (107 ± 11 ms vs. 100 ± 11 ms, P <0.001) and P-wave dispersion (45 ± 13 ms vs. 35 ± 13 ms, P <0.001) were found higher during migraine attacks than pain-free periods. We concluded that migraine attacks are associated with increased QTc and P-wave dispersion compared with pain-free periods.

Original languageEnglish (US)
Pages (from-to)672-677
Number of pages6
Issue number6
StatePublished - Jun 2006
Externally publishedYes


  • Autonomic nervous system
  • Electrocardiography
  • Migraine attacks
  • P-wave dispersion
  • QTc dispersion

ASJC Scopus subject areas

  • Clinical Neurology


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