Pyramidal cells in primary auditory cortex project to cochlear nucleus in rat

Diana L. Weedman, David K. Ryugo

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Recent work has demonstrated that the auditory cortex in rat sends direct projections to the auditory nuclei of the brainstem, including the cochlear nucleus and superior olive. To determine the cortical origin of the projections to cochlear nucleus, Fast Blue, a retrograde fluorescent tracer, was injected into the cochlear nucleus. Labeled cells in the forebrain were then studied with light microscopy and mapped. The projection was found to originate from large pyramidal neurons in layer V of primary auditory cortex. The projection was predominantly ipsilateral, and no labeled neurons were found in other cortical areas. These data imply that primary auditory cortex exerts influence over ascending auditory information at the earliest stages of the central auditory system.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalBrain research
Issue number1
StatePublished - Jan 8 1996


  • Auditory cortex
  • Cochlcar nucleus
  • Corticofugal
  • Efferent
  • Fast blue
  • Layer V

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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