Pyoderma Gangrenosum, Altered Delayed Hypersensitivity, and Polyarthritis

Gerald S. Lazarus; Lowell A. Goldsmith; Ross E. Rocklin; Robert S. Pinals; Jean Pierre Buisseret; John R. David; Cdr Will Draper

doi:10.1001/archderm.1972.01620040018003

Pyoderma Gangrenosum, Altered Delayed Hypersensitivity, and Polyarthritis

Gerald S. Lazarus, Lowell A. Goldsmith, Ross E. Rocklin, Robert S. Pinals, Jean Pierre Buisseret, John R. David, Cdr Will Draper

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

Four patients with pyoderma gangrenosum were found to have an abnormality of delayed hypersensitivity that was characterized by cutaneous anergy and dissociation between macrophage inhibitory factor production and blastogenic response in vitro. Three of these four patients had a rheumatoid-like polyarthritis. One patient responded to conservative therapy but three required high doses of corticosteroids for healing of the ulcers.

Original language	English (US)
Pages (from-to)	46-51
Number of pages	6
Journal	Archives of Dermatology
Volume	105
Issue number	1
DOIs	https://doi.org/10.1001/archderm.1972.01620040018003
State	Published - Jan 1972
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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10.1001/archderm.1972.01620040018003

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abstract = "Four patients with pyoderma gangrenosum were found to have an abnormality of delayed hypersensitivity that was characterized by cutaneous anergy and dissociation between macrophage inhibitory factor production and blastogenic response in vitro. Three of these four patients had a rheumatoid-like polyarthritis. One patient responded to conservative therapy but three required high doses of corticosteroids for healing of the ulcers.",

author = "Lazarus, {Gerald S.} and Goldsmith, {Lowell A.} and Rocklin, {Ross E.} and Pinals, {Robert S.} and Buisseret, {Jean Pierre} and David, {John R.} and Draper, {Cdr Will}",

year = "1972",

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AU - Pinals, Robert S.

AU - Buisseret, Jean Pierre

AU - David, John R.

AU - Draper, Cdr Will

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Pyoderma Gangrenosum, Altered Delayed Hypersensitivity, and Polyarthritis

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