Pyloric sphincter therapy: Botulinum toxin, stents, and pyloromyotomy

John O. Clarke, William J. Snape

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Gastroparesis is a syndrome characterized by delayed gastric emptying with associated symptoms. Gastric emptying is a complex process and pyloric dysfunction may play a key role in select subsets of patients with gastroparesis. Diagnostic tests to measure pyloric physiology are now available and have the potential to be more widely used in clinical practice. Targeted therapies including botulinum toxin, transpyloric stent placement, surgical pyloroplasty and endoscopic pyloromyotomy have been developed. Data are emerging regarding efficacy and durability, but these therapies may play a prominent role in select patients with gastroparesis and pyloric dysfunction.

Original languageEnglish (US)
Pages (from-to)127-136
Number of pages10
JournalGastroenterology Clinics of North America
Issue number1
StatePublished - Mar 1 2015


  • Botulinum toxin
  • Gastroparesis
  • Impedance planimetry
  • Pyloric stent
  • Pyloromyotomy
  • Pyloroplasty

ASJC Scopus subject areas

  • Gastroenterology


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