@article{26f6e22c541948c9ba39dc5e779c21bd,
title = "Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine",
abstract = "Hemozoin (malaria pigment) has been implicated in the modulation of immune responses during malaria infection. This study was designed to evaluate the effect of purified hemozoin on the in vitro activation of myeloid dendritic cells. Our study also revealed that in addition to enhancing the maturation of dendritic cells, hemozoin also greatly promotes immunoglobulin G2a antibody responses when coadministered with a DNA vaccine plasmid encoding Pfs25, a Plasmodium falciparum transmission-blocking antigen.",
author = "Cevayir Coban and Ishii, {Ken J.} and Sullivan, {David J.} and Nirbhay Kumar",
note = "Funding Information: We gratefully acknowledge support from the Leducq Foundation to A.S.M. and H.C.D., from the National Human Genome Research Institute (NHGRI) (1U54HG006542) to D.V. and J.L., from the National Heart, Lung, and Blood Institute (NHLBI) (HL110328, HL128745) and the NIH (S10OD012287) to J.T.B. We also thank the American Philosophical Society for support of H.A. through the Daland Fellowship. In addition, we thank Johns Hopkins University School of Medicine, McKusick Nathans Institute of Genetic Medicine Center for Functional Investigation in Zebrafish (FINZ) for their technical support and Corinne Boehm for her assistance in depositing variant information to ClinVar. B.L.L. is senior clinical investigator of the Fund for Scientific Research, Flanders, and holds a starting grant from the European Research Council (ERC-StG-2012-30972-BRAVE). A.V. is a postdoctoral researcher supported by the Fund for Scientific Research Flanders. I.L. is supported by a PhD grant from the Agency for Innovation by Science and Technology (IWT). M.E.L. is supported by the Toomey Fund for Aortic Dissection Research and the Fredman Fellowship in Aortic Disease. G.A. is a FQRS Senior Clinical Research Fellow.",
year = "2002",
doi = "10.1128/IAI.70.7.3939-3943.2002",
language = "English (US)",
volume = "70",
pages = "3939--3943",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "7",
}