Pulmonary Venous Hypertension

Andrew D. Lerner, Jess Mandel

Research output: Chapter in Book/Report/Conference proceedingChapter


Pulmonary venous hypertension (PVH) develops secondary to any left-sided heart disease associated with increased left atrial pressures. The classic hemodynamic profile in PVH is an elevated pulmonary artery pressure associated with an elevated pulmonary capillary wedge pressure and left ventricular enddiastolic pressure. There are two basic mechanisms in the pathophysiology of the disease: a passive component and a reactive component. In the passive form, pulmonary hypertension is a reflection of the passive downstream trans mission of elevated left heart pressures into the pulmonary vascular system. In the reactive form, a dysregulation of vascular smooth muscle tone and structural remodeling occur in the pulmonary vascular leading to elevated pulmonary arterial pressures considered “out of proportion” to the degree of left-sided heart disease. The main objective in the evaluation of PVH is to differentiate it from other forms of pulmonary. The mainstay treatment of PVH is directed at the cardiac dysfunction, rather than targeting the elevated pulmonary artery pressures alone.

Original languageEnglish (US)
Title of host publicationPanVascular Medicine, Second Edition
PublisherSpringer Berlin Heidelberg
Number of pages12
ISBN (Electronic)9783642370786
ISBN (Print)9783642370779
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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