TY - JOUR
T1 - Pulmonary manifestations of waldenstrom macroglobulinemia
AU - Rausch, P. Gregory
AU - Herion, John C.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1980/9
Y1 - 1980/9
N2 - Waldenstrom macroglobulinemia (WMG), a proliferation of malignant monoclonal IgM secreting plasmacytoid lymphocytes in lymph nodes, spleen, and marrow, usually pursues a chronic clinical course. A patient with WMG for five years who developed pulmonary tumors consisting of plasmacytoid lymphocytes prompted a review of the literature for pulmonary manifestations of WMG. Twenty‐six males and 18 females, ranging in age from 33 to 84 years, have been reported with histologically proven pulmonary involvement by WMG. The x‐ray findings, evident in most patients when first seen, consisted of masses (22 patients), infiltrates (31 patients), and pleural effusions (19 patients). Most patients (24) had two or more of these manifestations but only five, in addition to our patient, had isolated pulmonary nodules. Isolated pulmonary infiltrates were found in ten patients and isolated pleural effusions in only four. Symptoms at the onset of pulmonary involvement included dyspnea (54%), nonproductive cough (33%), and chest pain (7%); 15% were asymptomatic. Pulmonary manifestations, like other features of WMG, respond to alkylating agents or irradiation and do not appear to affect prognosis adversely. Pulmonary involvement should be suspected in any patient with WMG who develops an abnormal chest x‐ray.
AB - Waldenstrom macroglobulinemia (WMG), a proliferation of malignant monoclonal IgM secreting plasmacytoid lymphocytes in lymph nodes, spleen, and marrow, usually pursues a chronic clinical course. A patient with WMG for five years who developed pulmonary tumors consisting of plasmacytoid lymphocytes prompted a review of the literature for pulmonary manifestations of WMG. Twenty‐six males and 18 females, ranging in age from 33 to 84 years, have been reported with histologically proven pulmonary involvement by WMG. The x‐ray findings, evident in most patients when first seen, consisted of masses (22 patients), infiltrates (31 patients), and pleural effusions (19 patients). Most patients (24) had two or more of these manifestations but only five, in addition to our patient, had isolated pulmonary nodules. Isolated pulmonary infiltrates were found in ten patients and isolated pleural effusions in only four. Symptoms at the onset of pulmonary involvement included dyspnea (54%), nonproductive cough (33%), and chest pain (7%); 15% were asymptomatic. Pulmonary manifestations, like other features of WMG, respond to alkylating agents or irradiation and do not appear to affect prognosis adversely. Pulmonary involvement should be suspected in any patient with WMG who develops an abnormal chest x‐ray.
KW - lung infiltrates
KW - lung nodules
KW - macroglobulinemia
KW - pleural effusion
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U2 - 10.1002/ajh.2830090208
DO - 10.1002/ajh.2830090208
M3 - Article
C2 - 6776807
AN - SCOPUS:0019159229
SN - 0361-8609
VL - 9
SP - 201
EP - 209
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 2
ER -