Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.
|Original language||English (US)|
|Number of pages||3|
|Journal||Nature Cell Biology|
|State||Published - Mar 1 2017|
ASJC Scopus subject areas
- Cell Biology