Pulling cells out of tumours

Andrew Ewald

doi:10.1038/ncb3484

Pulling cells out of tumours

Andrew Ewald

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.

Original language	English (US)
Pages (from-to)	147-149
Number of pages	3
Journal	Nature Cell Biology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1038/ncb3484
State	Published - Mar 1 2017

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb3484

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title = "Pulling cells out of tumours",

abstract = "Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.",

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AB - Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.

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Pulling cells out of tumours

Abstract

ASJC Scopus subject areas

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