Pseudocorpus luteum insufficiency: A local defect of progesterone action on endometrial stroma

D. W. Keller, W. G. Wiest, F. B. Askin, L. W. Johnson, R. C. Strickler

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


A 23-yr-old woman whose initial complaint was infertility demonstrated glandular stromal dissociation with failure of the endometrial stroma to undergo pseudodecidualization in repeated endometrial biopsies taken late in the luteal phase. As the clinical presentation was consistent with the inadequate corpus luteum syndrome, hormone measurements were performed. The endometrial biopsy was abnormal during cycles in which the serum pattern of progesterone, estradiol, FSH, and LH was normal. Exogenous progesterone did not correct the abnormality. The patient, by in vitro studies, has approximately one half the number of high affinity progesterone-binding sites in the cytosol fraction of her endometrium compared to preparations from two normal contral subjects. Since her cytosolbinding protein was qualitatively identical to two control subjects, the incomplete maturation of her endometrial stroma may represent an absence or reduced number of stromal cytosol receptors and/or a resistance to specific hormone action in an individual target tissue.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number1
StatePublished - Jan 1979
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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