PSA-alpha-2-macroglobulin complex is enzymatically active in the serum of patients with advanced prostate cancer and can degrade circulating peptide hormones

Keyphrases

• Advanced Prostate Cancer 100%
• Prostate-specific Antigen 100%
• Alpha-2-macroglobulin 100%
• Peptide Hormone 100%
• Macroglobulin 82%
• Antichymotrypsin 82%
• Small Peptides 23%
• Prostate-specific Antigen Level 23%
• Interleukin-6 17%
• Peptide Substrate 17%
• Transforming Growth Factor-β 11%
• Prostate Cancer Cells 11%
• Enzymatic Activity 11%
• Parathyroid Hormone-related Protein (PTHrP) 11%
• ELISA Assay 11%
• Complex Formation 5%
• Protease Inhibitors 5%
• Growth Factors 5%
• Serine Protease 5%
• Cancer-specific 5%
• Tumor Microenvironment 5%
• Protein Substrate 5%
• Osteocalcin 5%
• Fluorescently Labeled 5%
• Proteolytic Degradation 5%
• Inhibitor-1 5%
• Serine Proteinase 5%
• Large Proteins 5%
• Labeled Peptide 5%
• Basic FGF 5%
• Antigen Production 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Prostate Cancer 100%
• Prostate Specific Antigen 100%
• Alpha 2 Macroglobulin 100%
• Peptide Hormone 100%
• Chymotrypsin Inhibitor 66%
• Enzyme-Linked Immunosorbent Assay 14%
• Cytokine 9%
• Transforming Growth Factor Beta 9%
• Malignant Neoplasm 4%
• Serine Proteinase 4%
• Proteinase Inhibitor 4%
• Tumor Antigen 4%
• Tumor Microenvironment 4%
• Growth Factor 4%
• Peptides and Proteins 4%
• Platelet Derived Growth Factor 4%
• Osteocalcin 4%

Biochemistry, Genetics and Molecular Biology

• Prostate-Specific Antigen 100%
• Peptide Hormone 100%
• Alpha-2-Macroglobulin 100%
• Macroglobulin 66%
• Enzymatic Hydrolysis 19%
• Cancer Cell 9%
• Transforming Growth Factor Beta 9%
• Cytokine 9%
• Enzyme Activity 9%
• Interleukin-6 9%
• Complex Formation 4%
• Growth Factor 4%
• Osteocalcin 4%
• Tumor Antigen 4%
• Protease Inhibitor 4%
• Serine Protease 4%
• Platelet-Derived Growth Factor 4%