Proton NMR spectroscopy of Canavan's disease

P. B. Barker; R. N. Bryan; A. J. Kumar; S. Naidu

doi:10.1055/s-2008-1071355

Proton NMR spectroscopy of Canavan's disease

P. B. Barker, R. N. Bryan, A. J. Kumar, S. Naidu

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42 Scopus citations

Abstract

Proton Nuclear Magnetic Resonance (NMR) spectroscopy was used to quantitatively determine cerebral N-Acetyl Aspartate (NAA) concentrations in four patients with Canavan's disease and in four age-matched control subjects. Macroscopic NAA concentrations (μmol/ gm wet weight) were not found to be significantly different from controls. Reduced levels of choline and creatine were observed in all patients, and increased levels of lactate and inositol in the eldest three patients.

Original language	English (US)
Pages (from-to)	263-267
Number of pages	5
Journal	Neuropediatrics
Volume	23
Issue number	5
DOIs	https://doi.org/10.1055/s-2008-1071355
State	Published - Jan 1 1992

Keywords

Canavan's disease
N-acetyl-aspartate
NMR spectroscopy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1055/s-2008-1071355

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AB - Proton Nuclear Magnetic Resonance (NMR) spectroscopy was used to quantitatively determine cerebral N-Acetyl Aspartate (NAA) concentrations in four patients with Canavan's disease and in four age-matched control subjects. Macroscopic NAA concentrations (μmol/ gm wet weight) were not found to be significantly different from controls. Reduced levels of choline and creatine were observed in all patients, and increased levels of lactate and inositol in the eldest three patients.

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KW - N-acetyl-aspartate

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Proton NMR spectroscopy of Canavan's disease

Abstract

Keywords

ASJC Scopus subject areas

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