Proton mr spectroscopy of experimental radiation-induced white matter injury

David M. Yousem, Robert E. Lenkinski, Sydney Evans, Debbie Allen, Robert O’Brien, Walter Curran, Mitchell Schnall, Max Bennett, Suzanne L. Wehrli, Robert I. Grossman

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We studied the spectroscopic appearance of radiation-induced my-elinolysis in cats to understand the characteristics of proton MR spectroscopy of demyelinating disorders. Eight cats received 5, 000 rads to a 1.5 x 1.5 cm area of the right cerebral hemisphere. Eight to 9 months after irradiation, a gross area of abnormal postcontrast enhancement and/or high MR signal in- tensity was detected in the irradiated hemisphere of six of the eight cats. Proton spectra of a 1.0 cm3voxel in the affected region demonstrated depressed A-acetyl aspartate/creatine-phosphocreatine and A-acetyl aspartate/ choline-containing compound peak ratios compared with the contralateral nonirradiated brain in all cats. Elevated amino acid resonances in the 2.0-2.5 ppm range were not consistently seen in irradiated zones of the brain with pathologic findings of demyelination. In vivo proton MR spectroscopy may show differences between irradiated brain and nonirradiated brain even when histopathologic lesions are not apparent yet

Original languageEnglish (US)
Pages (from-to)543-548
Number of pages6
JournalJournal of computer assisted tomography
Issue number4
StatePublished - Jul 1992
Externally publishedYes


  • Animal studies
  • Diseases
  • Injurious effects
  • Magnetic resonance spectroscopy
  • Radiation
  • White matter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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