Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions

Ty K. Subhawong, Xin Wang, Daniel J. Durand, Michael A. Jacobs, John A. Carrino, Antonio J. Machado, Laura M. Fayad

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


OBJECTIVE. The purposes of this review are to describe the principles and method of MR spectroscopy, summarize current published data on musculoskeletal lesions, and report additional cases that have been analyzed with recently developed quantitative methods. CONCLUSION. Proton MR spectroscopy can be used to identify key tissue metabolites and may serve as a useful adjunct to radiographic evaluation of musculoskeletal lesions. A pooled analysis of 122 musculoskeletal tumors revealed that a discrete choline peak has a sensitivity of 88% and specificity of 68% in the detection of malignancy. Modest improvements in diagnostic accuracy in 22 of 122 cases when absolute choline quantification was used encourage the pursuit of development of choline quantification methods.

Original languageEnglish (US)
Pages (from-to)162-172
Number of pages11
JournalAmerican Journal of Roentgenology
Issue number1
StatePublished - Jan 2012


  • Choline
  • MR spectroscopy
  • MRI
  • Musculoskeletal
  • Tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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