Proton MR spectroscopic imaging of the medulla and cervical spinal cord

Richard A.E. Edden; David Bonekamp; Mari A. Smith; Prachi Dubey; Peter B. Barker

doi:10.1002/jmri.21008

Proton MR spectroscopic imaging of the medulla and cervical spinal cord

Richard A.E. Edden, David Bonekamp, Mari A. Smith, Prachi Dubey, Peter B. Barker

School of Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Purpose: To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla. Materials and Methods: A method was developed for 1D-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. Results: High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 ± 0.5. 8.8 ± 1.8, and 10.9 ± 2.7 mM, respectively, while in the medulla they were 2.6 ± 0.5, 9.1 ± 1.7, and 10.8 ± 0.9 mM. Conclusion: Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla.

Original language	English (US)
Pages (from-to)	1101-1105
Number of pages	5
Journal	Journal of Magnetic Resonance Imaging
Volume	26
Issue number	4
DOIs	https://doi.org/10.1002/jmri.21008
State	Published - Oct 2007

Keywords

3 Tesla
Magnetic resonance spectroscopic imaging
Medulla
Metabolism
Spinal cord

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1002/jmri.21008

Cite this

@article{c223d2225cc24ca7bf1f64d57164a0c2,

title = "Proton MR spectroscopic imaging of the medulla and cervical spinal cord",

abstract = "Purpose: To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla. Materials and Methods: A method was developed for 1D-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. Results: High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 ± 0.5. 8.8 ± 1.8, and 10.9 ± 2.7 mM, respectively, while in the medulla they were 2.6 ± 0.5, 9.1 ± 1.7, and 10.8 ± 0.9 mM. Conclusion: Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla.",

keywords = "3 Tesla, Magnetic resonance spectroscopic imaging, Medulla, Metabolism, Spinal cord",

author = "Edden, {Richard A.E.} and David Bonekamp and Smith, {Mari A.} and Prachi Dubey and Barker, {Peter B.}",

year = "2007",

month = oct,

doi = "10.1002/jmri.21008",

language = "English (US)",

volume = "26",

pages = "1101--1105",

journal = "Journal of Magnetic Resonance Imaging",

issn = "1053-1807",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Proton MR spectroscopic imaging of the medulla and cervical spinal cord

AU - Edden, Richard A.E.

AU - Bonekamp, David

AU - Smith, Mari A.

AU - Dubey, Prachi

AU - Barker, Peter B.

PY - 2007/10

Y1 - 2007/10

N2 - Purpose: To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla. Materials and Methods: A method was developed for 1D-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. Results: High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 ± 0.5. 8.8 ± 1.8, and 10.9 ± 2.7 mM, respectively, while in the medulla they were 2.6 ± 0.5, 9.1 ± 1.7, and 10.8 ± 0.9 mM. Conclusion: Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla.

AB - Purpose: To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla. Materials and Methods: A method was developed for 1D-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. Results: High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 ± 0.5. 8.8 ± 1.8, and 10.9 ± 2.7 mM, respectively, while in the medulla they were 2.6 ± 0.5, 9.1 ± 1.7, and 10.8 ± 0.9 mM. Conclusion: Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla.

KW - 3 Tesla

KW - Magnetic resonance spectroscopic imaging

KW - Medulla

KW - Metabolism

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=35148894182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35148894182&partnerID=8YFLogxK

U2 - 10.1002/jmri.21008

DO - 10.1002/jmri.21008

M3 - Article

C2 - 17896355

AN - SCOPUS:35148894182

SN - 1053-1807

VL - 26

SP - 1101

EP - 1105

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

IS - 4

ER -

Proton MR spectroscopic imaging of the medulla and cervical spinal cord

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this