Proton MR spectroscopic imaging of the medulla and cervical spinal cord

Richard A.E. Edden, David Bonekamp, Mari A. Smith, Prachi Dubey, Peter B. Barker

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Purpose: To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla. Materials and Methods: A method was developed for 1D-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. Results: High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 ± 0.5. 8.8 ± 1.8, and 10.9 ± 2.7 mM, respectively, while in the medulla they were 2.6 ± 0.5, 9.1 ± 1.7, and 10.8 ± 0.9 mM. Conclusion: Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla.

Original languageEnglish (US)
Pages (from-to)1101-1105
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Issue number4
StatePublished - Oct 2007


  • 3 Tesla
  • Magnetic resonance spectroscopic imaging
  • Medulla
  • Metabolism
  • Spinal cord

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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