Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: A pilot investigation comparing treatment responders and non-responders

Mona A. Mohamed; Mari A. Smith; Michael W. Schlund; Gerald Nestadt; Peter B. Barker; Rudolf Hoehn-Saric

doi:10.1016/j.pscychresns.2007.04.002

Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: A pilot investigation comparing treatment responders and non-responders

Mona A. Mohamed, Mari A. Smith, Michael W. Schlund, Gerald Nestadt, Peter B. Barker, Rudolf Hoehn-Saric

School of Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Proton magnetic resonance spectroscopic imaging was performed to compare brain metabolism in patients with obsessive-compulsive OCD. Evaluation was done on responders and non-responders to pharmacotherapy and on healthy controls. The results showed significantly lower NAA/Cr ratios in the right basal ganglia in non-responders than in responders or in controls and higher Cho/Cr ratios in the right thalamus in non-responders than responders. Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Psychiatry Research - Neuroimaging
Volume	156
Issue number	2
DOIs	https://doi.org/10.1016/j.pscychresns.2007.04.002
State	Published - Nov 15 2007

Keywords

OCD
SSRI
brain metabolism
treatment non-responders
treatment responders

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/j.pscychresns.2007.04.002

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title = "Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: A pilot investigation comparing treatment responders and non-responders",

abstract = "Proton magnetic resonance spectroscopic imaging was performed to compare brain metabolism in patients with obsessive-compulsive OCD. Evaluation was done on responders and non-responders to pharmacotherapy and on healthy controls. The results showed significantly lower NAA/Cr ratios in the right basal ganglia in non-responders than in responders or in controls and higher Cho/Cr ratios in the right thalamus in non-responders than responders. Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor.",

keywords = "OCD, SSRI, brain metabolism, treatment non-responders, treatment responders",

author = "Mohamed, {Mona A.} and Smith, {Mari A.} and Schlund, {Michael W.} and Gerald Nestadt and Barker, {Peter B.} and Rudolf Hoehn-Saric",

note = "Funding Information: The research reported was supported by the Johns Hopkins University School of Medicine General Clinical Research Center, Grant #MO1-RR00052 from the National Center for Research Resources/NIH (RHS) and NIH P41 RR15241 (PBB, MAS, MAM).",

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AU - Schlund, Michael W.

AU - Nestadt, Gerald

AU - Barker, Peter B.

AU - Hoehn-Saric, Rudolf

N1 - Funding Information: The research reported was supported by the Johns Hopkins University School of Medicine General Clinical Research Center, Grant #MO1-RR00052 from the National Center for Research Resources/NIH (RHS) and NIH P41 RR15241 (PBB, MAS, MAM).

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KW - SSRI

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KW - treatment responders

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Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: A pilot investigation comparing treatment responders and non-responders

Abstract

Keywords

ASJC Scopus subject areas

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