Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma

Bayram Cirak; Alena Horska; Peter B. Barker; Peter C. Burger; Benjamin S. Carson; Anthony M. Avellino

doi:10.1007/s00381-004-1023-2

Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma

Bayram Cirak, Alena Horska, Peter B. Barker, Peter C. Burger, Benjamin S. Carson, Anthony M. Avellino

School of Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Objects: A pilomyxoid astrocytoma (PmA) is considered to be either a more aggressive variant of a pediatric pilocytic astrocytoma (PA) or a tumor of a separate entity. Methods: We present two cases of pediatric optic-chiasmatic PmA. Proton magnetic resonance spectroscopic imaging (MRSI) of the PmA revealed decreased concentrations of total choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA). In contrast, proton MR spectra of PAs showed elevated Cho and decreased Cr and NAA signals. Conclusion: Low metabolite concentrations in PmAs detected by MRSI may therefore help to distinguish PmAs from PAs preoperatively.

Original language	English (US)
Pages (from-to)	404-409
Number of pages	6
Journal	Child's Nervous System
Volume	21
Issue number	5
DOIs	https://doi.org/10.1007/s00381-004-1023-2
State	Published - May 2005

Keywords

Pediatric brain tumor
Pilocytic astrocytoma
Pilomyxoid astrocytoma
Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1007/s00381-004-1023-2

Cite this

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title = "Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma",

abstract = "Objects: A pilomyxoid astrocytoma (PmA) is considered to be either a more aggressive variant of a pediatric pilocytic astrocytoma (PA) or a tumor of a separate entity. Methods: We present two cases of pediatric optic-chiasmatic PmA. Proton magnetic resonance spectroscopic imaging (MRSI) of the PmA revealed decreased concentrations of total choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA). In contrast, proton MR spectra of PAs showed elevated Cho and decreased Cr and NAA signals. Conclusion: Low metabolite concentrations in PmAs detected by MRSI may therefore help to distinguish PmAs from PAs preoperatively.",

keywords = "Pediatric brain tumor, Pilocytic astrocytoma, Pilomyxoid astrocytoma, Proton magnetic resonance spectroscopy",

author = "Bayram Cirak and Alena Horska and Barker, {Peter B.} and Burger, {Peter C.} and Carson, {Benjamin S.} and Avellino, {Anthony M.}",

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T1 - Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma

AU - Cirak, Bayram

AU - Horska, Alena

AU - Barker, Peter B.

AU - Burger, Peter C.

AU - Carson, Benjamin S.

AU - Avellino, Anthony M.

PY - 2005/5

Y1 - 2005/5

N2 - Objects: A pilomyxoid astrocytoma (PmA) is considered to be either a more aggressive variant of a pediatric pilocytic astrocytoma (PA) or a tumor of a separate entity. Methods: We present two cases of pediatric optic-chiasmatic PmA. Proton magnetic resonance spectroscopic imaging (MRSI) of the PmA revealed decreased concentrations of total choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA). In contrast, proton MR spectra of PAs showed elevated Cho and decreased Cr and NAA signals. Conclusion: Low metabolite concentrations in PmAs detected by MRSI may therefore help to distinguish PmAs from PAs preoperatively.

AB - Objects: A pilomyxoid astrocytoma (PmA) is considered to be either a more aggressive variant of a pediatric pilocytic astrocytoma (PA) or a tumor of a separate entity. Methods: We present two cases of pediatric optic-chiasmatic PmA. Proton magnetic resonance spectroscopic imaging (MRSI) of the PmA revealed decreased concentrations of total choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA). In contrast, proton MR spectra of PAs showed elevated Cho and decreased Cr and NAA signals. Conclusion: Low metabolite concentrations in PmAs detected by MRSI may therefore help to distinguish PmAs from PAs preoperatively.

KW - Pediatric brain tumor

KW - Pilocytic astrocytoma

KW - Pilomyxoid astrocytoma

KW - Proton magnetic resonance spectroscopy

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Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma

Abstract

Keywords

ASJC Scopus subject areas

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