Proteomic studies of HIV-1 and its posttranslational modifications

David R. Colquhoun; David Graham

doi:10.1007/978-1-4939-6542-7_6

Proteomic studies of HIV-1 and its posttranslational modifications

David R. Colquhoun, David Graham

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

HIV requires many proteins to complete its life cycle. Many of these proteins are decorated with biologically critical modifications that alter structure and function. In fact, there are many different types of posttranslational modifications (PTMs) involved in the virus life cycle (Fig. 6.1). In this chapter, we will reintroduce the virus life cycle from the perspective of PTMs. While these modifications will be described in detail later in the chapter, we will highlight new modifications in bold as they are introduced.

Original language	English (US)
Title of host publication	HIV-1 Proteomics: From Discovery to Clinical Application
Publisher	Springer New York
Pages	77-97
Number of pages	21
ISBN (Electronic)	9781493965427
ISBN (Print)	9781493965403
DOIs	https://doi.org/10.1007/978-1-4939-6542-7_6
State	Published - Jan 1 2016

Keywords

Acylation
Click chemistry
Glycosylation
HIV-1
Myristoylation
Palmitoylation
Phosphorylation
Posttranslational modifications
Ubiquitination

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

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10.1007/978-1-4939-6542-7_6

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KW - Glycosylation

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KW - Phosphorylation

KW - Posttranslational modifications

KW - Ubiquitination

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Proteomic studies of HIV-1 and its posttranslational modifications

Abstract

Keywords

ASJC Scopus subject areas

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