Proteomic studies of HIV-1 and its posttranslational modifications

David R. Colquhoun, David Graham

Research output: Chapter in Book/Report/Conference proceedingChapter


HIV requires many proteins to complete its life cycle. Many of these proteins are decorated with biologically critical modifications that alter structure and function. In fact, there are many different types of posttranslational modifications (PTMs) involved in the virus life cycle (Fig. 6.1). In this chapter, we will reintroduce the virus life cycle from the perspective of PTMs. While these modifications will be described in detail later in the chapter, we will highlight new modifications in bold as they are introduced.

Original languageEnglish (US)
Title of host publicationHIV-1 Proteomics: From Discovery to Clinical Application
PublisherSpringer New York
Number of pages21
ISBN (Electronic)9781493965427
ISBN (Print)9781493965403
StatePublished - Jan 1 2016


  • Acylation
  • Click chemistry
  • Glycosylation
  • HIV-1
  • Myristoylation
  • Palmitoylation
  • Phosphorylation
  • Posttranslational modifications
  • Ubiquitination

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


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