Proteomic Analysis of the Human Anterior Pituitary Gland

Soujanya D. Yelamanchi; Ankur Tyagi; Varshasnata Mohanty; Pinaki Dutta; Márta Korbonits; Sandip Chavan; Jayshree Advani; Anil K. Madugundu; Gourav Dey; Keshava K. Datta; M. Rajyalakshmi; Nandini A. Sahasrabuddhe; Abhishek Chaturvedi; Amit Kumar; Apabrita Ayan Das; Dhiman Ghosh; Gajendra M. Jogdand; Haritha H. Nair; Keshav Saini; Manoj Panchal; Mansi Ashwinsinh Sarvaiya; Soundappan S. Mohanraj; Nabonita Sengupta; Priti Saxena; Pradeep Annamalai Subramani; Pradeep Kumar; Rakhil Akkali; Saraswatipura Vishwabrahmachar Reshma; Ramachandran Sarojini Santhosh; Sangita Rastogi; Sudarshan Kumar; Susanta Kumar Ghosh; Vamshi Krishna Irlapati; Anand Srinivasan; Bishan Das Radotra; Premendu P. Mathur; G. William Wong; Parthasarathy Satishchandra; Aditi Chatterjee; Harsha Gowda; Anil Bhansali; Akhilesh Pandey; Susarla K. Shankar; Anita Mahadevan; T. S.Keshava Prasad

doi:10.1089/omi.2018.0160

Proteomic Analysis of the Human Anterior Pituitary Gland

Soujanya D. Yelamanchi, Ankur Tyagi, Varshasnata Mohanty, Pinaki Dutta, Márta Korbonits, Sandip Chavan, Jayshree Advani, Anil K. Madugundu, Gourav Dey, Keshava K. Datta, M. Rajyalakshmi, Nandini A. Sahasrabuddhe, Abhishek Chaturvedi, Amit Kumar, Apabrita Ayan Das, Dhiman Ghosh, Gajendra M. Jogdand, Haritha H. Nair, Keshav Saini, Manoj PanchalMansi Ashwinsinh Sarvaiya, Soundappan S. Mohanraj, Nabonita Sengupta, Priti Saxena, Pradeep Annamalai Subramani, Pradeep Kumar, Rakhil Akkali, Saraswatipura Vishwabrahmachar Reshma, Ramachandran Sarojini Santhosh, Sangita Rastogi, Sudarshan Kumar, Susanta Kumar Ghosh, Vamshi Krishna Irlapati, Anand Srinivasan, Bishan Das Radotra, Premendu P. Mathur, G. William Wong, Parthasarathy Satishchandra, Aditi Chatterjee, Harsha Gowda, Anil Bhansali, Akhilesh Pandey, Susarla K. Shankar, Anita Mahadevan, T. S.Keshava Prasad

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.

Original language	English (US)
Pages (from-to)	759-769
Number of pages	11
Journal	OMICS A Journal of Integrative Biology
Volume	22
Issue number	12
DOIs	https://doi.org/10.1089/omi.2018.0160
State	Published - 2018

Keywords

anterior pituitary
biomarkers
diagnostics
endocrinology
ophthalmology
proteomics

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Medicine
Molecular Biology
Genetics

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10.1089/omi.2018.0160

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Yelamanchi, S. D., Tyagi, A., Mohanty, V., Dutta, P., Korbonits, M., Chavan, S., Advani, J., Madugundu, A. K., Dey, G., Datta, K. K., Rajyalakshmi, M., Sahasrabuddhe, N. A., Chaturvedi, A., Kumar, A., Das, A. A., Ghosh, D., Jogdand, G. M., Nair, H. H., Saini, K., ... Prasad, T. S. K. (2018). Proteomic Analysis of the Human Anterior Pituitary Gland. OMICS A Journal of Integrative Biology, 22(12), 759-769. https://doi.org/10.1089/omi.2018.0160

Yelamanchi, SD, Tyagi, A, Mohanty, V, Dutta, P, Korbonits, M, Chavan, S, Advani, J, Madugundu, AK, Dey, G, Datta, KK, Rajyalakshmi, M, Sahasrabuddhe, NA, Chaturvedi, A, Kumar, A, Das, AA, Ghosh, D, Jogdand, GM, Nair, HH, Saini, K, Panchal, M, Sarvaiya, MA, Mohanraj, SS, Sengupta, N, Saxena, P, Subramani, PA, Kumar, P, Akkali, R, Reshma, SV, Santhosh, RS, Rastogi, S, Kumar, S, Ghosh, SK, Irlapati, VK, Srinivasan, A, Radotra, BD, Mathur, PP, Wong, GW, Satishchandra, P, Chatterjee, A, Gowda, H, Bhansali, A, Pandey, A, Shankar, SK, Mahadevan, A & Prasad, TSK 2018, 'Proteomic Analysis of the Human Anterior Pituitary Gland', OMICS A Journal of Integrative Biology, vol. 22, no. 12, pp. 759-769. https://doi.org/10.1089/omi.2018.0160

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title = "Proteomic Analysis of the Human Anterior Pituitary Gland",

abstract = "The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.",

keywords = "anterior pituitary, biomarkers, diagnostics, endocrinology, ophthalmology, proteomics",

author = "Yelamanchi, {Soujanya D.} and Ankur Tyagi and Varshasnata Mohanty and Pinaki Dutta and M{\'a}rta Korbonits and Sandip Chavan and Jayshree Advani and Madugundu, {Anil K.} and Gourav Dey and Datta, {Keshava K.} and M. Rajyalakshmi and Sahasrabuddhe, {Nandini A.} and Abhishek Chaturvedi and Amit Kumar and Das, {Apabrita Ayan} and Dhiman Ghosh and Jogdand, {Gajendra M.} and Nair, {Haritha H.} and Keshav Saini and Manoj Panchal and Sarvaiya, {Mansi Ashwinsinh} and Mohanraj, {Soundappan S.} and Nabonita Sengupta and Priti Saxena and Subramani, {Pradeep Annamalai} and Pradeep Kumar and Rakhil Akkali and Reshma, {Saraswatipura Vishwabrahmachar} and Santhosh, {Ramachandran Sarojini} and Sangita Rastogi and Sudarshan Kumar and Ghosh, {Susanta Kumar} and Irlapati, {Vamshi Krishna} and Anand Srinivasan and Radotra, {Bishan Das} and Mathur, {Premendu P.} and Wong, {G. William} and Parthasarathy Satishchandra and Aditi Chatterjee and Harsha Gowda and Anil Bhansali and Akhilesh Pandey and Shankar, {Susarla K.} and Anita Mahadevan and Prasad, {T. S.Keshava}",

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T1 - Proteomic Analysis of the Human Anterior Pituitary Gland

AU - Yelamanchi, Soujanya D.

AU - Tyagi, Ankur

AU - Mohanty, Varshasnata

AU - Dutta, Pinaki

AU - Korbonits, Márta

AU - Chavan, Sandip

AU - Advani, Jayshree

AU - Madugundu, Anil K.

AU - Dey, Gourav

AU - Datta, Keshava K.

AU - Rajyalakshmi, M.

AU - Sahasrabuddhe, Nandini A.

AU - Chaturvedi, Abhishek

AU - Kumar, Amit

AU - Das, Apabrita Ayan

AU - Ghosh, Dhiman

AU - Jogdand, Gajendra M.

AU - Nair, Haritha H.

AU - Saini, Keshav

AU - Panchal, Manoj

AU - Sarvaiya, Mansi Ashwinsinh

AU - Mohanraj, Soundappan S.

AU - Sengupta, Nabonita

AU - Saxena, Priti

AU - Subramani, Pradeep Annamalai

AU - Kumar, Pradeep

AU - Akkali, Rakhil

AU - Reshma, Saraswatipura Vishwabrahmachar

AU - Santhosh, Ramachandran Sarojini

AU - Rastogi, Sangita

AU - Kumar, Sudarshan

AU - Ghosh, Susanta Kumar

AU - Irlapati, Vamshi Krishna

AU - Srinivasan, Anand

AU - Radotra, Bishan Das

AU - Mathur, Premendu P.

AU - Wong, G. William

AU - Satishchandra, Parthasarathy

AU - Chatterjee, Aditi

AU - Gowda, Harsha

AU - Bhansali, Anil

AU - Pandey, Akhilesh

AU - Shankar, Susarla K.

AU - Mahadevan, Anita

AU - Prasad, T. S.Keshava

PY - 2018

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N2 - The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.

AB - The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.

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KW - biomarkers

KW - diagnostics

KW - endocrinology

KW - ophthalmology

KW - proteomics

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JO - OMICS A Journal of Integrative Biology

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Proteomic Analysis of the Human Anterior Pituitary Gland

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