Protein tyrosine kinases Src and Csk: A tail's tale

Philip A. Cole, Kui Shen, Yingfeng Qiao, Dongxia Wang

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Csk and Src are two protein tyrosine kinases with similar amino acid sequences but very different structures and functions. Csk catalyzes a tail phosphorylation reaction on Src and thereby restrains Src's activity and oncogenic potential. Comparative analysis of the domain interactions in these enzymes provides a lesson in signalling diversity and mechanisms of enzyme regulation. The molecular basis of the specificity of Csk targeting the Src tail appears to involve both local and long-range interactions and illustrates the complexity of selective targeting in post-translational modification.

Original languageEnglish (US)
Pages (from-to)580-585
Number of pages6
JournalCurrent Opinion in Chemical Biology
Issue number5
StatePublished - Oct 2003
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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