Protein turnover in HIV- infected children

R. Headerson, K. Talusan, N. Hutton, R. Yolken, B. Caballero

Research output: Contribution to journalArticlepeer-review


To explore the mechanisms by which HIV infection results in growth retardation, protein turnover (Q), snynthesis (S), and catabolism (C) were assessed using the 15N-glycine end product method. HIV+ children with growth retardation (HIV+Gr), defined as height/age or weight/height <-1.5- Z-scores below the NCHS median, were compared with HIV+ and HIV children with normal growth. All were free of acute, febrile illness at time of study. Twenty-four children between 2 and 11 years of age were studied. Although not statistically significant, mean Q, S, and C were higher in HIV+Gr compared to HIV+ and HIV-, and higher in HIV+ than HIV-. (Figure Presented) Conclusion: These results suggest a trend towards increased protein turnover in HIV+ children, which may play a role in growth retardation. Further studies are needed, as small sample size may have precluded the power to detect statistically significant different differences between the groups.

Original languageEnglish (US)
Pages (from-to)A364
JournalFASEB Journal
Issue number3
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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