Protein S-nitrosylation: A physiological signal for neuronal nitric oxide

Samie R. Jaffrey, Hediye Erdjument-Bromage, Christopher D. Ferris, Paul Tempst, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

1173 Scopus citations


Nitric oxide (NO) has been linked to numerous physiological and pathophysiological events that are not readily explained by the well established effects of NO on soluble guanylyl cyclase. Exogenous NO S-nitrosylates cysteine residues in proteins, but whether this is an important function of endogenous NO is unclear. Here, using a new proteomic approach, we identify a population of proteins that are endogenously S-nitrosylated, and demonstrate the loss of this modification in mice harbouring a genomic deletion of neuronal NO synthase (nNOS). Targets of NO include metabolic, structural and signalling proteins that may be effectors for neuronally generated NO. These findings establish protein S-nitrosylation as a physiological signalling mechanism for nNOS.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalNature cell biology
Issue number2
StatePublished - 2001

ASJC Scopus subject areas

  • Cell Biology


Dive into the research topics of 'Protein S-nitrosylation: A physiological signal for neuronal nitric oxide'. Together they form a unique fingerprint.

Cite this