Protein binding of vancomycin in a patient with immunoglobulin A myeloma

T. G. Cantu; J. D. Dick; D. E. Elliott; R. L. Humphrey; D. M. Kornhauser

doi:10.1128/AAC.34.7.1459

Protein binding of vancomycin in a patient with immunoglobulin A myeloma

T. G. Cantu, J. D. Dick, D. E. Elliott, R. L. Humphrey, D. M. Kornhauser

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Abstract

Atypical vancomycin pharmacokinetics were observed in an immunoglobulin A myeloma patient. Drug concentrations in serum were extremely elevated, the elimination half-life was prolonged despite normal renal function, and the vancomycin therapy was ineffective. Extensive binding of vancomycin, presumably by high concentrations of an aberrant immunoglobulin A protein, may have accounted for these observations.

Original language	English (US)
Pages (from-to)	1459-1461
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	34
Issue number	7
DOIs	https://doi.org/10.1128/AAC.34.7.1459
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.34.7.1459

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abstract = "Atypical vancomycin pharmacokinetics were observed in an immunoglobulin A myeloma patient. Drug concentrations in serum were extremely elevated, the elimination half-life was prolonged despite normal renal function, and the vancomycin therapy was ineffective. Extensive binding of vancomycin, presumably by high concentrations of an aberrant immunoglobulin A protein, may have accounted for these observations.",

author = "Cantu, {T. G.} and Dick, {J. D.} and Elliott, {D. E.} and Humphrey, {R. L.} and Kornhauser, {D. M.}",

year = "1990",

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AU - Dick, J. D.

AU - Elliott, D. E.

AU - Humphrey, R. L.

AU - Kornhauser, D. M.

PY - 1990

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AB - Atypical vancomycin pharmacokinetics were observed in an immunoglobulin A myeloma patient. Drug concentrations in serum were extremely elevated, the elimination half-life was prolonged despite normal renal function, and the vancomycin therapy was ineffective. Extensive binding of vancomycin, presumably by high concentrations of an aberrant immunoglobulin A protein, may have accounted for these observations.

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Protein binding of vancomycin in a patient with immunoglobulin A myeloma

Abstract

ASJC Scopus subject areas

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