Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

Keyphrases

• Aggregate Formation 25%
• Aggresome 50%
• Apoptosis Induction 25%
• Ataxia Telangiectasia mutated 25%
• Cancer Therapy 25%
• Cell Death 25%
• Cellular Effects 25%
• Cellular Process 25%
• Checkpoint Kinase 1 (CHK1) 25%
• Control Cell 25%
• CRM1 25%
• Cyclin 25%
• Cyclin-dependent Kinase 25%
• Deubiquitinase 25%
• DNA Repair Response 25%
• DNA Stress 25%
• Export Pathways 25%
• Human Tissue 25%
• In Cancer 25%
• Inactivity 25%
• Inhibitor Treatment 25%
• Mammalian Cell Lines 25%
• Mammalian Cells 25%
• Marker Proteins 25%
• Mechanistic Insights 25%
• Misfolded Proteins 25%
• Nuclear Stress Bodies 25%
• Nucleolar 100%
• Nucleolus 100%
• Oncogenesis 25%
• P53 Protein 25%
• Protease Inhibitors 100%
• Proteasome Activity 50%
• Protein Aggregates 25%
• Protein Quality Control 25%
• Protein Transport 25%
• Reticulum Stress 25%
• Retinoblastoma Protein 25%
• Ribosomal RNA 25%
• Ribosomal RNA Synthesis 25%
• RNA Export 25%
• RNA Surveillance 25%
• RNA-protein Complex 25%
• RNA-RNA 25%
• Signaling Molecules 25%
• Stress Response 50%
• Synthetic Activity 25%
• Transcription Factor p53 25%
• Ubiquitin 100%
• Ubiquitin-proteasome Pathway 25%
• Ubiquitination Pathway 25%

Biochemistry, Genetics and Molecular Biology

• Aggresome 33%
• Ataxia Telangiectasia Mutated 16%
• Carcinogenesis 16%
• Cell Cycle 33%
• Cell Death 16%
• Chromosome Regions 16%
• Cyclin 16%
• Cyclin-Dependent Kinase 16%
• DNA Repair 16%
• Nucleolus 66%
• P53 16%
• Programmed Cell Death 16%
• Proteasome 100%
• Proteasome Inhibitor 100%
• Protein Quality Control 16%
• Retinoblastoma Protein 33%
• Ribosomal RNA 33%
• RNA 100%
• Signaling Protein 16%
• Transcription 16%
• Transcription Factors 16%
• Transport Protein 16%
• Ubiquitin 100%