Prostate stem cells and cancer

Alexander Yu Nikitin, A. Matoso, P. Roy-Burman

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Properties shared by neoplastic and stem cells indicate a possibility that somatic stem cells or transit-amplifying cells that have reacquired stem cell properties, particularly the ability for self-renewal, represent favorable targets for malignant transformation. In this review we discuss significance of the stem cell model for understanding prostate cancer pathogenesis and describe relevant studies in animals. It is proposed that dissemination of rare cancer stem cells may lead to metastatic disease and that resistance of such cells to multiple drugs and androgen ablation make them responsible for failure of current treatments. Thus further understanding of the cancer stem cell biology is needed for development of efficient rationally designed therapy permitting better targeting and better treatment outcomes for patients with prostate neoplasms.

Original languageEnglish (US)
Pages (from-to)1043-1049
Number of pages7
JournalHistology and Histopathology
Issue number7-9
StatePublished - Jul 2007
Externally publishedYes


  • Adult stem cells
  • Androgen ablation
  • Carcinogenesis
  • Mouse models
  • Neuroendocrine differentiation
  • Prostate

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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