Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer: An Update on Important Pitfalls

Sara Sheikhbahaei, Rudolf A. Werner, Lilja B. Solnes, Kenneth J. Pienta, Martin G. Pomper, Michael A. Gorin, Steven P. Rowe

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The continuing adoption of prostate specific membrane antigen (PSMA)-targeted PET for prostate cancer molecular imaging requires imagers and clinicians alike to be aware of the increasing number of potential interpretive pitfalls that have been reported. This review summarizes and illustrates the spectrum of benign and malignant nonprostatic conditions with high PSMA-radiotracer uptake that may be mistaken for sites of prostate cancer and also discusses potential false negatives. We discuss the recent literature on the effect of androgen deprivation therapy on lesion detection. Furthermore, we briefly review the recently proposed structured reporting systems for the standardized interpretation of PSMA-targeted PET that can guide both imaging specialists and referring clinicians in the appropriate interpretation and work-up of pitfalls.

Original languageEnglish (US)
Pages (from-to)255-270
Number of pages16
JournalSeminars in Nuclear Medicine
Issue number4
StatePublished - Jul 2019

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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