TY - JOUR
T1 - Prostanoids and pain
T2 - Unraveling mechanisms and revealing therapeutic targets
AU - Samad, Tarek A.
AU - Sapirstein, Adam
AU - Woolf, Clifford J.
PY - 2002
Y1 - 2002
N2 - Advances in our understanding of the synthesis, regulation and function of prostanoids have led to a new appreciation of their actions in health and disease. Prostanoid synthesis is essential for the generation of inflammatory pain and this depends not only on prostanoid production at the site of inflammation, but also on the actions of prostanoids synthesized within the central nervous system (CNS). Moreover, central prostanoid synthesis is controlled both by neural and humoral signals, the latter being a novel form of input to the CNS. Diverse compounds that act along the pathway of prostanoid synthesis and action, both in the periphery and in the CNS, might provide increased benefit for treating inflammatory pain hypersensitivity and its associated sickness syndrome, with a reduced risk of adverse effects.
AB - Advances in our understanding of the synthesis, regulation and function of prostanoids have led to a new appreciation of their actions in health and disease. Prostanoid synthesis is essential for the generation of inflammatory pain and this depends not only on prostanoid production at the site of inflammation, but also on the actions of prostanoids synthesized within the central nervous system (CNS). Moreover, central prostanoid synthesis is controlled both by neural and humoral signals, the latter being a novel form of input to the CNS. Diverse compounds that act along the pathway of prostanoid synthesis and action, both in the periphery and in the CNS, might provide increased benefit for treating inflammatory pain hypersensitivity and its associated sickness syndrome, with a reduced risk of adverse effects.
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U2 - 10.1016/S1471-4914(02)02383-3
DO - 10.1016/S1471-4914(02)02383-3
M3 - Review article
C2 - 12127725
AN - SCOPUS:0036316688
SN - 1471-4914
VL - 8
SP - 390
EP - 396
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 8
ER -