TY - JOUR
T1 - Prospective preference assessment of patients' willingness to participate in a randomized controlled trial of intensity-modulated radiotherapy versus proton therapy for localized prostate cancer
AU - Shah, Anand
AU - Efstathiou, Jason A.
AU - Paly, Jonathan J.
AU - Halpern, Scott D.
AU - Bruner, Deborah W.
AU - Christodouleas, John P.
AU - Coen, John J.
AU - Deville, Curtiland
AU - Vapiwala, Neha
AU - Shipley, William U.
AU - Zietman, Anthony L.
AU - Hahn, Stephen M.
AU - Bekelman, Justin E.
N1 - Funding Information:
Supported by a health services research fellowship from the University of Pennsylvania Department of Radiation Oncology (A.S.).
PY - 2012/5/1
Y1 - 2012/5/1
N2 - Purpose: To investigate patients' willingness to participate (WTP) in a randomized controlled trial (RCT) comparing intensity-modulated radiotherapy (IMRT) with proton beam therapy (PBT) for prostate cancer (PCa). Methods and Materials: We undertook a qualitative research study in which we prospectively enrolled patients with clinically localized PCa. We used purposive sampling to ensure a diverse sample based on age, race, travel distance, and physician. Patients participated in a semi-structured interview in which they reviewed a description of a hypothetical RCT, were asked open-ended and focused follow-up questions regarding their motivations for and concerns about enrollment, and completed a questionnaire assessing characteristics such as demographics and prior knowledge of IMRT or PBT. Patients' stated WTP was assessed using a 6-point Likert scale. Results: Forty-six eligible patients (33 white, 13 black) were enrolled from the practices of eight physicians. We identified 21 factors that impacted patients' WTP, which largely centered on five major themes: altruism/desire to compare treatments, randomization, deference to physician opinion, financial incentives, and time demands/scheduling. Most patients (27 of 46, 59%) stated they would either "definitely" or "probably" participate. Seventeen percent (8 of 46) stated they would "definitely not" or "probably not" enroll, most of whom (6 of 8) preferred PBT before their physician visit. Conclusions: A substantial proportion of patients indicated high WTP in a RCT comparing IMRT and PBT for PCa.
AB - Purpose: To investigate patients' willingness to participate (WTP) in a randomized controlled trial (RCT) comparing intensity-modulated radiotherapy (IMRT) with proton beam therapy (PBT) for prostate cancer (PCa). Methods and Materials: We undertook a qualitative research study in which we prospectively enrolled patients with clinically localized PCa. We used purposive sampling to ensure a diverse sample based on age, race, travel distance, and physician. Patients participated in a semi-structured interview in which they reviewed a description of a hypothetical RCT, were asked open-ended and focused follow-up questions regarding their motivations for and concerns about enrollment, and completed a questionnaire assessing characteristics such as demographics and prior knowledge of IMRT or PBT. Patients' stated WTP was assessed using a 6-point Likert scale. Results: Forty-six eligible patients (33 white, 13 black) were enrolled from the practices of eight physicians. We identified 21 factors that impacted patients' WTP, which largely centered on five major themes: altruism/desire to compare treatments, randomization, deference to physician opinion, financial incentives, and time demands/scheduling. Most patients (27 of 46, 59%) stated they would either "definitely" or "probably" participate. Seventeen percent (8 of 46) stated they would "definitely not" or "probably not" enroll, most of whom (6 of 8) preferred PBT before their physician visit. Conclusions: A substantial proportion of patients indicated high WTP in a RCT comparing IMRT and PBT for PCa.
KW - Intensity-modulated radiotherapy
KW - Prostate cancer
KW - Proton beam therapy
KW - Randomized controlled trial
UR - http://www.scopus.com/inward/record.url?scp=84859823555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859823555&partnerID=8YFLogxK
U2 - 10.1016/j.ijrobp.2011.11.072
DO - 10.1016/j.ijrobp.2011.11.072
M3 - Article
C2 - 22381899
AN - SCOPUS:84859823555
SN - 0360-3016
VL - 83
SP - e13-e19
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 1
ER -