TY - JOUR
T1 - Prospective association between manganese in early pregnancy and the risk of preeclampsia
AU - Liu, Tiange
AU - Hivert, Marie France
AU - Rifas-Shiman, Sheryl L.
AU - Rahman, Mohammad L.
AU - Oken, Emily
AU - Cardenas, Andres
AU - Mueller, Noel T.
N1 - Funding Information:
Project Viva is funded by grants from the U.S. National Institutes of Health (R01 HD034568, UH3 OD023286). N.T.M. was supported by the Na-tional Heart, Lung, and Blood Institute grant (K01HL141589). Data used in this study were generated through grants supported by the National Institute of Environmental Health Sciences (U2CES026561) as part of the Children’s Environmental Health Analysis Resource (CHEAR; project #2017-1740). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Health or any of its components.
Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Background: Manganese, an essential micronutrient, has been found in lower concentrations among women with preeclampsia in cross-sectional and case-control studies without establishment of a temporal relationship. Methods: We evaluated the prospective association of manganese (in red blood cells) in first trimester of pregnancy with incidence of preeclampsia (ascertained by reviewing medical records) among 1,312 women in eastern Massachusetts (Project Viva, 1999-2002). We used log-binomial regression to examine the manganese-preeclampsia relationship, adjusting for maternal age, race/ethnicity, parity, prepregnancy body mass index, blood pressure, and hematocrit. Results: The median (25th, 75th percentile) manganese concentrationin red blood cells was 16.2 ng/g (13.1, 20.4) and 48 (4%) women developed preeclampsia. We observed an inverse dose-response relationship between manganese and preeclampsia. Compared with women in the lowest tertile, women in the middle manganese tertile had 0.81 times the risk of preeclampsia (95% CI: 0.43, 1.5) and those in the highest tertile had 0.50 (95% CI: 0.25, 0.99) times the risk. Conclusions: Our results provide insight into a potentially modifiable way to prevent preeclampsia.
AB - Background: Manganese, an essential micronutrient, has been found in lower concentrations among women with preeclampsia in cross-sectional and case-control studies without establishment of a temporal relationship. Methods: We evaluated the prospective association of manganese (in red blood cells) in first trimester of pregnancy with incidence of preeclampsia (ascertained by reviewing medical records) among 1,312 women in eastern Massachusetts (Project Viva, 1999-2002). We used log-binomial regression to examine the manganese-preeclampsia relationship, adjusting for maternal age, race/ethnicity, parity, prepregnancy body mass index, blood pressure, and hematocrit. Results: The median (25th, 75th percentile) manganese concentrationin red blood cells was 16.2 ng/g (13.1, 20.4) and 48 (4%) women developed preeclampsia. We observed an inverse dose-response relationship between manganese and preeclampsia. Compared with women in the lowest tertile, women in the middle manganese tertile had 0.81 times the risk of preeclampsia (95% CI: 0.43, 1.5) and those in the highest tertile had 0.50 (95% CI: 0.25, 0.99) times the risk. Conclusions: Our results provide insight into a potentially modifiable way to prevent preeclampsia.
KW - Manganese
KW - Preeclampsia
KW - Pregnancy
KW - Prevention
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U2 - 10.1097/EDE.0000000000001227
DO - 10.1097/EDE.0000000000001227
M3 - Article
C2 - 32618710
AN - SCOPUS:85089125617
SN - 1044-3983
VL - 31
SP - 677
EP - 680
JO - Epidemiology
JF - Epidemiology
IS - 5
ER -