Prospective association between hypotension and idiopathic chronic fatigue

Katherine E. Lucas, Peter C. Rowe, Josef Coresh, Michael J. Klag, Lucy A. Meoni, Daniel E. Ford

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: To determine whether there is an association between hypotension and incident cases of idiopathic chronic fatigue. Design: A prospective study. Setting: Johns Hopkins Precursors Study. Participants: Medical students (n = 876) in graduating classes from 1948 to 1964. Main outcome measure: 'Easy fatigability' reported by participants at 5- or 10-year follow-up after graduation. Results: The unadjusted risk in women was 5.0 (95% exact confidence interval = 1.4 to 17.4) and in men was 1.7 (95% exact confidence interval = 0.8, to 3.5). Conclusion: These preliminary findings suggest that hypotension may be a risk factor for the development of idiopathic chronic fatigue in women.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalJournal of hypertension
Issue number4
StatePublished - Apr 2004


  • Chronic fatigue
  • Hypotension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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