Propagation wavefronts in two-dimensional topologies of cardiac cell networks

Matthew G. Fishler, Nitish V. Thakor, Philip Reidt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


We present a computer model, implemented on a Cray-2 supercomputer, to explore the role of the discontinuous, nonuniform, and anisotropic cellular structure of cardiac tissue on normal propagation patterns. For this study, we hold cell shape constant and evaluate planar propagation wavefronts oriented longitudinally and transversely to the cell axis for two different tissue topologies-rectangular and brick-like-and for different degrees of transverse coupling strengths between cells. Nonuniformity is introduced into the model via spatial dispersions of coupling strengths. Even under severe conditions of uncoupling, both topologies show remarkable abilities in maintaining a uniformly planar wavefront. Thus, our simulations suggest that cardiac cell networks are very robust in their abilities to equilibrate electrical spatial inhomogeneities, even in the face of significant structural and coupling inhomogeneities.

Original languageEnglish (US)
Title of host publicationProceedings - Computers in Cardiology, CIC 1992
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages4
ISBN (Electronic)0818635525, 9780818635526
StatePublished - 1992
Event1992 IEEE Conference on Computers in Cardiology, CIC 1992 - Durham, United States
Duration: Oct 11 1992Oct 14 1992

Publication series

NameProceedings - Computers in Cardiology, CIC 1992


Conference1992 IEEE Conference on Computers in Cardiology, CIC 1992
Country/TerritoryUnited States

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering


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