Proof of concept for the role of glycemic control in the early detection of infections in diabetics

Taxiarchis Botsis, Albert M. Lai, George Hripcsak, Walter Palmas, Justin B. Starren, Gunnar Hartvigsen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The relationship of infections and glycemic control in diabetes has been previously investigated but no solid findings have been described. Meanwhile, the detection of any infection at the early stages of disease progression, i.e. during the incubation period, is critical. In order to study this topic, we used the infection evidence and the daily glycemic control data of 248 type-2 diabetics who participated in a large telemedicine study. The results showed that morning blood glucose was significantly elevated and that diabetics performed the measurements at a later time when infected. A simple model for predicting the occurrence of infection based on the glycemic control variables showed good performance (sensitivity: 56%, specificity: 92%). A set of variables that synthesize a diabetic's profile could be included in a dedicated model and facilitate the early detection of infections; other aspects, such as continuous self-monitoring and personalized medical records, should be examined in this direction.

Original languageEnglish (US)
Pages (from-to)26-35
Number of pages10
JournalHealth informatics journal
Issue number1
StatePublished - Mar 2012
Externally publishedYes


  • blood glucose
  • diabetes mellitus
  • early detection of disease
  • incubation period
  • infection

ASJC Scopus subject areas

  • Health Informatics


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