TY - JOUR
T1 - Prolonged survival in bronchogenic carcinoma associated with HL A antigens W 19 and HL A5
T2 - a preliminary report
AU - Dellon, A. L.
AU - Rogentine, G. N.
AU - Chretien, P. B.
PY - 1975
Y1 - 1975
N2 - The HL A antigens were determined retrospectively in a group of 14 surgically cured bronchogenic carcinoma patients and prospectively in another group of 100 untreated patients. In the retrospective group, the frequencies of antigens W 19 and HL A5 were significantly increased when compared with the noncancer control and the prospective lung cancer populations. In the latter group, 60% of the patients with W 19 and 58% with HL A5 survived without evidence of tumour for at least 1 year after treatment compared with 15% of patients with neither of these antigens, P less than 0.01 and 0.005, respectively. These comparisons were for adenocarcinoma and squamous carcinoma. The patient groups for oat cell and undifferentiated carcinoma were too small for valid statistical comparisons. This preliminary study suggests that the presence of HL A antigens W 19 and HL A5 confers resistance to dissemination of bronchogenic carcinoma.
AB - The HL A antigens were determined retrospectively in a group of 14 surgically cured bronchogenic carcinoma patients and prospectively in another group of 100 untreated patients. In the retrospective group, the frequencies of antigens W 19 and HL A5 were significantly increased when compared with the noncancer control and the prospective lung cancer populations. In the latter group, 60% of the patients with W 19 and 58% with HL A5 survived without evidence of tumour for at least 1 year after treatment compared with 15% of patients with neither of these antigens, P less than 0.01 and 0.005, respectively. These comparisons were for adenocarcinoma and squamous carcinoma. The patient groups for oat cell and undifferentiated carcinoma were too small for valid statistical comparisons. This preliminary study suggests that the presence of HL A antigens W 19 and HL A5 confers resistance to dissemination of bronchogenic carcinoma.
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U2 - 10.1093/jnci/54.6.1283
DO - 10.1093/jnci/54.6.1283
M3 - Article
C2 - 1133845
AN - SCOPUS:0016767393
SN - 0027-8874
VL - 54
SP - 1283
EP - 1286
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 6
ER -