Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study

J. Saiz; J. M. Ferrero; J. Chorro; M. Monserrat; V. Torres; J. M. Ferrero; N. V. Thakor

Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study

J. Saiz, J. M. Ferrero, J. Chorro, M. Monserrat, V. Torres, J. M. Ferrero, N. V. Thakor

Research output: Contribution to journal › Conference article › peer-review

Abstract

The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. Our results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast I_Na current may be partially responsible for the ERP prolongation.

Original language	English (US)
Pages (from-to)	709-712
Number of pages	4
Journal	Computers in cardiology
State	Published - 1997
Externally published	Yes
Event	Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden Duration: Sep 7 1997 → Sep 10 1997

ASJC Scopus subject areas

Computer Science Applications
Cardiology and Cardiovascular Medicine

Cite this

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title = "Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study",

abstract = "The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. Our results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast INa current may be partially responsible for the ERP prolongation.",

author = "J. Saiz and Ferrero, {J. M.} and J. Chorro and M. Monserrat and V. Torres and Ferrero, {J. M.} and Thakor, {N. V.}",

year = "1997",

language = "English (US)",

pages = "709--712",

journal = "Computers in cardiology",

issn = "0276-6574",

publisher = "IEEE Computer Society",

note = "Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology ; Conference date: 07-09-1997 Through 10-09-1997",

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TY - JOUR

T1 - Prolongation of refractoriness by trains of subthreshold high-frequency stimuli

T2 - Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology

AU - Saiz, J.

AU - Ferrero, J. M.

AU - Chorro, J.

AU - Monserrat, M.

AU - Torres, V.

AU - Ferrero, J. M.

AU - Thakor, N. V.

PY - 1997

Y1 - 1997

N2 - The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. Our results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast INa current may be partially responsible for the ERP prolongation.

AB - The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. Our results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast INa current may be partially responsible for the ERP prolongation.

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UR - http://www.scopus.com/inward/citedby.url?scp=0031337291&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0031337291

SN - 0276-6574

SP - 709

EP - 712

JO - Computers in cardiology

JF - Computers in cardiology

Y2 - 7 September 1997 through 10 September 1997

ER -

Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study

Abstract

ASJC Scopus subject areas

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