Proline biosynthesis: Multiple defects in Chinese hamster ovary cells

David Valle, Sylvia J. Downing, Shirley C. Harris, James M. Phang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The biochemical basis for the proline requirement of Chinese hamster ovary cells has been investigated. The results indicate an absence of conversion of glutamate to proline and a 90% reduction in ornithine transaminase, the first enzyme in the pathway converting ornithine to proline. Possible explanations for this double defect are discussed.

Original languageEnglish (US)
Pages (from-to)1130-1136
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Aug 21 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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