Proliferative Retinopathy in Sickle Cell Trait: Report of Seven Cases

Krishan C. Nagpal, George K. Asdourian, Dimitrios Patrianakos, Morton F. Goldberg, Maurice F. Rabb, Michael Goldbaum, Motilal Raichand

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Seven patients had sickle cell trait (hemoglobin AS) and vasoproliferative retinopathy. The retinal abnormalities in these seven patients were indistinguishable from those seen in patients with clinically significant sickling hemoglobinopathies (sickle cell-hemoglobin C disease, hemoglobin S-thalassemia disease, and sickle cell anemia). All seven patients also had some evidence of associated systemic disease such as diabetes, syphilis, tuberculosis, or sarcoidosis. In the presence of an associated systemic disease, marked retinopathy can occur in the ordinarily benign condition of sickle cell trait.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalArchives of internal medicine
Issue number3
StatePublished - Mar 1977
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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