Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands.

Daniel Rudmann; Robert Cardiff; Luc Chouinard; Dawn Goodman; Karin Küttler; Heike Marxfeld; Alfredo Molinolo; Silke Treumann; Katsuhiko Yoshizawa; Mammary, Zymbal's, Preputial, INHAND Mammary, Zymbal's, Preputial,

doi:10.1177/0192623312454242

Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands.

Daniel Rudmann, Robert Cardiff, Luc Chouinard, Dawn Goodman, Karin Küttler, Heike Marxfeld, Alfredo Molinolo, Silke Treumann, Katsuhiko Yoshizawa, Mammary, Zymbal's, Preputial, INHAND Mammary, Zymbal's, Preputial,

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The mammary gland of laboratory rodents is an important organ for the evaluation of effects of xenobiotics, especially those that perturb hormonal homeostasis or are potentially carcinogenic. Mammary gland cancer is a leading cause of human mortality and morbidity worldwide and is a subject of major research efforts utilizing rodent models. Zymbal's, preputial, and clitoral glands are standard tissues that are evaluated in animal models that enable human risk assessment of xenobiotics. A widely accepted and utilized international harmonization of nomenclature for mammary, Zymbal's, preputial, and clitoral gland lesions in laboratory animals will improve diagnostic alignment among regulatory and scientific research organizations and enrich international exchanges of information among toxicologists and pathologists.

Original language	English (US)
Pages (from-to)	7S-39S
Journal	Toxicologic pathology
Volume	40
Issue number	6 Suppl
DOIs	https://doi.org/10.1177/0192623312454242
State	Published - Aug 2012
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Toxicology
Cell Biology

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Rudmann, D., Cardiff, R., Chouinard, L., Goodman, D., Küttler, K., Marxfeld, H., Molinolo, A., Treumann, S., Yoshizawa, K., & INHAND Mammary, Zymbal's, Preputial, M. Z. P. (2012). Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicologic pathology, 40(6 Suppl), 7S-39S. https://doi.org/10.1177/0192623312454242

Rudmann, D, Cardiff, R, Chouinard, L, Goodman, D, Küttler, K, Marxfeld, H, Molinolo, A, Treumann, S, Yoshizawa, K & INHAND Mammary, Zymbal's, Preputial, MZP 2012, 'Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands.', Toxicologic pathology, vol. 40, no. 6 Suppl, pp. 7S-39S. https://doi.org/10.1177/0192623312454242

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AU - Küttler, Karin

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AU - Treumann, Silke

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Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands.

Abstract

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