Projecting the age-distribution of men who have sex with men receiving HIV treatment in the United States

Parastu Kasaie, Cameron Stewart, Elizabeth Humes, Lucas Gerace, Jinbing Zhang, Michael J. Silverberg, Michael A. Horberg, Peter F. Rebeiro, Emily P. Hyle, Viviane D. Lima, Cherise Wong, M. John Gill, Kelly Gebo, Richard Moore, Mari M. Kitahata, Keri N. Althoff

Research output: Contribution to journalArticlepeer-review


Background: The age-distribution of men who have sex with men (MSM) continues to change in the ‘Treat-All’ era as effective test-and-treat programs target key-populations. However, the nature of these changes and potential racial heterogeneities remain uncertain. Methods: The PEARL model is an agent-based simulation of MSM in HIV care in the US, calibrated to data from the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Results: PEARL projects a gradual decrease in median age of MSM at ART initiation from 36 to 31 years during 2010–2030, accompanied by changes in mortality among Black, White, and Hispanic MSM on ART by -8.4%, 42.4% and -19.6%. The median age of all MSM on ART is projected to increase from 45 to 47 years from 2010–2030, with the proportion of ART-users age ≥60y increasing from 6.7% to 28.0%. Almost half (49.7%) of White MSM ART-users are projected to age ≥60y by 2030, compared to 19.5% of Black and 17.2% of Hispanic MSM. Conclusions: The overall age of US MSM in HIV care is expected to increase over the next decade, and differentially by race/ethnicity. As this population age, HIV programs should expand care for age-related causes of morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)46-55
Number of pages10
JournalAnnals of epidemiology
StatePublished - Jan 2022


  • Aging
  • Computer simulation
  • HIV
  • Hispanic ethnicity
  • People who inject drugs
  • Racial disparities
  • Sexual and Gender Minorities

ASJC Scopus subject areas

  • Epidemiology


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