Progress toward HIV eradication: Case reports, current efforts, and the challenges associated with cure

Alyssa R. Martin; Robert F. Siliciano

doi:10.1146/annurev-med-011514-023043

Progress toward HIV eradication: Case reports, current efforts, and the challenges associated with cure

Alyssa R. Martin, Robert F. Siliciano

Howard Hughes Medical Institution

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

An estimated 35 million people worldwide are infected with HIV, yet a widely applicable cure strategy remains elusive. Recent case reports have suggested that curing HIV infection is possible, renewing excitement about research efforts. We describe those cases and discuss their relevance to the global HIV epidemic. We also review ongoing cure strategies that are transitioning from the lab to the clinic, and the assays and clinical assessments that can be used to evaluate cure interventions.

Original language	English (US)
Pages (from-to)	215-228
Number of pages	14
Journal	Annual review of medicine
Volume	67
DOIs	https://doi.org/10.1146/annurev-med-011514-023043
State	Published - Jan 14 2016

Keywords

Early treatment
Genome editing
HIV-1
Persistence
Shock and kill
Vaccine

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1146/annurev-med-011514-023043

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abstract = "An estimated 35 million people worldwide are infected with HIV, yet a widely applicable cure strategy remains elusive. Recent case reports have suggested that curing HIV infection is possible, renewing excitement about research efforts. We describe those cases and discuss their relevance to the global HIV epidemic. We also review ongoing cure strategies that are transitioning from the lab to the clinic, and the assays and clinical assessments that can be used to evaluate cure interventions.",

keywords = "Early treatment, Genome editing, HIV-1, Persistence, Shock and kill, Vaccine",

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AU - Siliciano, Robert F.

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AB - An estimated 35 million people worldwide are infected with HIV, yet a widely applicable cure strategy remains elusive. Recent case reports have suggested that curing HIV infection is possible, renewing excitement about research efforts. We describe those cases and discuss their relevance to the global HIV epidemic. We also review ongoing cure strategies that are transitioning from the lab to the clinic, and the assays and clinical assessments that can be used to evaluate cure interventions.

KW - Early treatment

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KW - Shock and kill

KW - Vaccine

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Progress toward HIV eradication: Case reports, current efforts, and the challenges associated with cure

Abstract

Keywords

ASJC Scopus subject areas

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