Progress in the rational design of an AIDS vaccine

Gary J. Nabel; Peter D. Kwong; John R. Mascola

doi:10.1098/rstb.2011.0096

Progress in the rational design of an AIDS vaccine

Gary J. Nabel, Peter D. Kwong, John R. Mascola

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Human immunodeficiency virus-1 (HIV-1) has a high degree of genetic and antigenic diversity that has impeded the development of an effective vaccine using traditional methods. We are attempting to develop an AIDS vaccine by employing strategies that include structural biology and computational modelling, in an effort to develop immunogens capable of eliciting neutralizing antibodies of the requisite breadth and potency against circulating strains of HIV-1.

Original language	English (US)
Pages (from-to)	2759-2765
Number of pages	7
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	366
Issue number	1579
DOIs	https://doi.org/10.1098/rstb.2011.0096
State	Published - Oct 12 2011
Externally published	Yes

Keywords

Antibody response
Computational techniques
HIV-1
Informatics
Structural biology
Vaccine design

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1098/rstb.2011.0096

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Progress in the rational design of an AIDS vaccine

Abstract

Keywords

ASJC Scopus subject areas

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