Programmed Multidrug Delivery Based on Bio-Inspired Capsule-Integrated Nanocoatings for Infected Bone Defect Treatment

Shichao Zhang, Justin Vaida, Josh Parenti, Brock A. Lindsey, Malcolm Xing, Bingyun Li

Research output: Contribution to journalArticlepeer-review

Abstract

Infection and delayed wound healing are two major serious complications related to traumatic injuries and cause a significant burden to patients and society. Most currently available drug delivery materials typically carry a single drug, lack protection from drug loading, and face challenges in on-demand and precisely controlled drug release. Here, we report a flower (Cirsium arvense)-inspired capsule-integrated multilayer nanofilm (FICIF), synthesized using a layer-by-layer self-assembly, for programmed multiple drug co-delivery for trauma (open fracture as an example) treatments. Our approach allows polypeptide multilayer nanofilms and innovative impregnated capsules to assemble hierarchical reservoirs with specific drug binding sites, shielding protection capability, and ordered packing structures. The resultant FICIF nanocarriers enable sustained and on-demand co-delivery of a unique immune-tuning cytokine (interleukin 12p70) and a growth factor (bone morphogenetic protein 2) in clinical use, resulting in extraordinary anti-infection (3 orders of magnitude improved bacterial killing) and bone regeneration (5 times enhanced bone healing) in treating infected rat femur fractures. The successful synthesis of these biomimetic high-performance delivery nanocoatings is expected to serve as a source of inspiration for the development of biomaterials for various clinical applications.

Original languageEnglish (US)
Pages (from-to)12454-12462
Number of pages9
JournalACS Applied Materials and Interfaces
Volume13
Issue number10
DOIs
StatePublished - Mar 17 2021
Externally publishedYes

Keywords

  • anti-infection
  • bone regeneration
  • drug delivery
  • fracture
  • implant nanocoating
  • self-assembly
  • trauma

ASJC Scopus subject areas

  • General Materials Science

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