Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma

Arjen M. Rijken; Akiko Umezawa; Thomas M. Van Gulik; Anne Bosma; Mirjam M. Polak; G. Johan A Offerhaus; Huug Obertop; Dirk J. Gouma

Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma

Arjen M. Rijken, Akiko Umezawa, Thomas M. Van Gulik, Anne Bosma, Mirjam M. Polak, G. Johan A Offerhaus, Huug Obertop, Dirk J. Gouma

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: The aim of this study was to investigate the prognostic value of celt proliferation (Ki-67 antigen) and DNA content in patients resected for distal bile duct carcinoma (DBDC). Methods: Formalin-fixed tumor specimens of 35 patients with resected DBDC and a long-term clinical follow- up were analyzed. MIB-1 antibody was used for Ki-67 antigen detection to determine the proportion of proliferating cells. DNA content was measured using flow cytometry. Results: A significant correlation was found between a low MIB-1 index (

Original language	English (US)
Pages (from-to)	699-705
Number of pages	7
Journal	Annals of Surgical Oncology
Volume	5
Issue number	8
State	Published - Dec 1998
Externally published	Yes

Keywords

Bile duct carcinoma
Cell proliferation
Ki-67 antigen
Nuclear DNA content
Prognostication

ASJC Scopus subject areas

Surgery
Oncology

Cite this

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title = "Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma",

abstract = "Background: The aim of this study was to investigate the prognostic value of celt proliferation (Ki-67 antigen) and DNA content in patients resected for distal bile duct carcinoma (DBDC). Methods: Formalin-fixed tumor specimens of 35 patients with resected DBDC and a long-term clinical follow- up were analyzed. MIB-1 antibody was used for Ki-67 antigen detection to determine the proportion of proliferating cells. DNA content was measured using flow cytometry. Results: A significant correlation was found between a low MIB-1 index (",

keywords = "Bile duct carcinoma, Cell proliferation, Ki-67 antigen, Nuclear DNA content, Prognostication",

author = "Rijken, {Arjen M.} and Akiko Umezawa and {Van Gulik}, {Thomas M.} and Anne Bosma and Polak, {Mirjam M.} and Offerhaus, {G. Johan A} and Huug Obertop and Gouma, {Dirk J.}",

year = "1998",

month = dec,

language = "English (US)",

volume = "5",

pages = "699--705",

journal = "Annals of Surgical Oncology",

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T1 - Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma

AU - Rijken, Arjen M.

AU - Umezawa, Akiko

AU - Van Gulik, Thomas M.

AU - Bosma, Anne

AU - Polak, Mirjam M.

AU - Offerhaus, G. Johan A

AU - Obertop, Huug

AU - Gouma, Dirk J.

PY - 1998/12

Y1 - 1998/12

N2 - Background: The aim of this study was to investigate the prognostic value of celt proliferation (Ki-67 antigen) and DNA content in patients resected for distal bile duct carcinoma (DBDC). Methods: Formalin-fixed tumor specimens of 35 patients with resected DBDC and a long-term clinical follow- up were analyzed. MIB-1 antibody was used for Ki-67 antigen detection to determine the proportion of proliferating cells. DNA content was measured using flow cytometry. Results: A significant correlation was found between a low MIB-1 index (

AB - Background: The aim of this study was to investigate the prognostic value of celt proliferation (Ki-67 antigen) and DNA content in patients resected for distal bile duct carcinoma (DBDC). Methods: Formalin-fixed tumor specimens of 35 patients with resected DBDC and a long-term clinical follow- up were analyzed. MIB-1 antibody was used for Ki-67 antigen detection to determine the proportion of proliferating cells. DNA content was measured using flow cytometry. Results: A significant correlation was found between a low MIB-1 index (

KW - Bile duct carcinoma

KW - Cell proliferation

KW - Ki-67 antigen

KW - Nuclear DNA content

KW - Prognostication

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JF - Annals of Surgical Oncology

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Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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